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Tchem
MPO
Myeloperoxidase

Protein Summary
Description
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225275
  • ENSP00000225275
  • ENSG00000005381
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
disease
0.9
drug
0.88
cellular component
0.86


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4945.96   (req: < 5)
Gene RIFs: 415   (req: <= 3)
Antibodies: 1584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4945.96   (req: >= 5)
Gene RIFs: 415   (req: > 3)
Antibodies: 1584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 117
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
hydralazine
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloperoxidase measurement
2
3
3
93.7
monocyte percentage of leukocytes
2
4
5
76
blood protein measurement
1
1
1
70.3
neutrophil percentage of leukocytes
2
3
4
68
basophil percentage of leukocytes
1
2
2
65.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloperoxidase measurement
3
93.7
monocyte percentage of leukocytes
5
76
blood protein measurement
1
70.3
neutrophil percentage of leukocytes
4
68
basophil percentage of leukocytes
2
65.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloperoxidase
VGNC:9442
748680
Macaque
myeloperoxidase
714246
Mouse
MGI:97137
17523
Dog
myeloperoxidase
VGNC:43341
609986
Horse
myeloperoxidase
VGNC:20288
100070920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloperoxidase
Macaque
myeloperoxidase
Mouse
Dog
myeloperoxidase
Horse
myeloperoxidase
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05164-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Events associated with phagocytolytic activity of PMN cells (R-HSA-8941413)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Events associated with phagocytolytic activity of PMN cells
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
ROS and RNS production in phagocytes
Name
Explore in Pharos
Explore in Source
Events associated with phagocytolytic activity of PMN cells
Immune System
Innate Immune System
Neutrophil degranulation
ROS and RNS production in phagocytes
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (376)
1 – 10 of 376
ICE2
Tbio
Novelty: 0.03407933
p_int: 0.99999908
p_ni: 3.91e-7
p_wrong: 5.29e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.999997586
p_ni: 0.000001353
p_wrong: 0.000001061
Score: 0.256
Data Source: BioPlex,STRINGDB
APCDD1
Tbio
Novelty: 0.25122542
p_int: 0.99999131
p_ni: 0.000008672
p_wrong: 1.7e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
PLB1
Tbio
Family: Enzyme
Novelty: 0.01628403
p_int: 0.999827172
p_ni: 0.00001532
p_wrong: 0.000157507
Score: 0.386
Data Source: BioPlex,STRINGDB
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.996
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.995
Data Source: STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.989
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.985
Data Source: STRINGDB
AZU1
Tbio
Family: Enzyme
Novelty: 0.00267169
Score: 0.985
Data Source: STRINGDB
BPI
Tbio
Novelty: 0.00229665
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  4945.96

PubMed score by year
PubTator Score  5992.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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