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Tbio
LGALS2
Galectin-2

Protein Summary
Description
This protein binds beta-galactoside. Its physiological function is not yet known. The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215886
  • ENSP00000215886
  • ENSG00000100079

Symbol
  • HL14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
PubMedID
0.7
biological term
0.46
tissue sample
0.45
disease
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.89   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.89   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
LTA
Tbio
Novelty:  0.00100413
Score:  0.674
Data Source:  STRINGDB
GCSAM
Tbio
Novelty:  0.02682289
Score:  0.592
Data Source:  STRINGDB
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.567
Data Source:  STRINGDB
PAICS
Tchem
Novelty:  0.00215277
Score:  0.505
Data Source:  STRINGDB
IGSF23
Tdark
Novelty:  3.21746057
Score:  0.461
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.444
Data Source:  STRINGDB
ALOX5AP
Tchem
Family:  Enzyme
Novelty:  0.00165143
Score:  0.443
Data Source:  STRINGDB
NXPE1
Tdark
Novelty:  1.36399926
Score:  0.428
Data Source:  STRINGDB
PSMA6
Tbio
Family:  Enzyme
Novelty:  0.01525994
Score:  0.424
Data Source:  STRINGDB
NAT8
Tbio
Family:  Enzyme
Novelty:  0.02178437
Score:  0.409
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
3
3
88.7
cup-to-disc ratio measurement
3
3
4
88.4
optic disc area measurement
3
3
5
81.4
serum albumin measurement
1
1
1
50.6
myeloid white cell count
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
3
88.7
cup-to-disc ratio measurement
4
88.4
optic disc area measurement
5
81.4
serum albumin measurement
1
50.6
myeloid white cell count
1
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 2
VGNC:10090
470204
Macaque
galectin 2
697820
Mouse
MGI:895068
107753
Rat
RGD:621269
171134
Dog
galectin 2
VGNC:42647
474514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 2
Macaque
galectin 2
Mouse
Rat
Dog
galectin 2
Publication Statistics
PubMed Score 12.89
PubMed score by year
PubTator Score 81.71
PubTator score by year
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Related Publications
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PMID
Year
Title