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Tbio
ISG15
Ubiquitin-like protein ISG15

Protein Summary
Description
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379389
  • ENSP00000368699
  • ENSG00000187608
  • ENST00000649529
  • ENSP00000496832

Symbol
  • G1P2
  • UCRP
  • G1P2
  • IP17
  • UCRP
  • IFI15
  • IMD38
  • hUCRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.96
small molecule perturbation
0.88
transcription factor perturbation
0.8
biological term
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.03   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 525   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.03   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
59.6
apolipoprotein A 1 measurement
2
2
2
52
high density lipoprotein cholesterol measurement
2
2
2
47.4
alkaline phosphatase measurement
1
1
1
46.9
hip bone size
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
59.6
apolipoprotein A 1 measurement
2
52
high density lipoprotein cholesterol measurement
2
47.4
alkaline phosphatase measurement
1
46.9
hip bone size
1
31.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin-like protein ISG15
100609237
Macaque
ISG15 ubiquitin-like modifier
700141
Mouse
MGI:1855694
100038882
Rat
RGD:1310312
298693
Dog
ISG15 ubiquitin-like modifier
VGNC:42106
100855667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin-like protein ISG15
Macaque
ISG15 ubiquitin-like modifier
Mouse
Rat
Dog
ISG15 ubiquitin-like modifier
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DNA Damage Bypass
DNA Repair
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (523)
1 – 10 of 523
IFNA2
Tbio
Novelty:  0.00032935
p_int:  0.999998155
p_ni:  0.000001742
p_wrong:  1.03e-7
Score:  0.96
Data Source:  BioPlex,STRINGDB
IFNW1
Tbio
Novelty:  0.1308421
p_int:  0.99999758
p_ni:  0.000002414
p_wrong:  6e-9
Score:  0.627
Data Source:  BioPlex,STRINGDB
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.999989149
p_ni:  0.000010844
p_wrong:  8e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.999982215
p_ni:  0.000017664
p_wrong:  1.21e-7
Score:  0.85
Data Source:  BioPlex,STRINGDB
TNK2
Tclin
Family:  Kinase
Novelty:  0.00921397
p_int:  0.999975164
p_ni:  0.00000885
p_wrong:  0.000015986
Score:  0.274
Data Source:  BioPlex,STRINGDB
IFNA10
Tbio
Novelty:  0.04848204
p_int:  0.999863743
p_ni:  0.000136255
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.999829099
p_ni:  0.000170849
p_wrong:  5.2e-8
Score:  0.926
Data Source:  BioPlex,STRINGDB
IFNA14
Tbio
Novelty:  0.17853653
p_int:  0.999744555
p_ni:  0.000232521
p_wrong:  0.000022923
Score:  0.875
Data Source:  BioPlex,STRINGDB
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999739268
p_ni:  0.000202887
p_wrong:  0.000057845
Score:  0.886
Data Source:  BioPlex,STRINGDB
IFNA8
Tbio
Novelty:  0.0310922
p_int:  0.999626893
p_ni:  0.000013606
p_wrong:  0.000359501
Score:  0.802
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  558.03

PubMed score by year
PubTator Score  266.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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