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Tbio
CFI
Complement factor I

Protein Summary
Description
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394634
  • ENSP00000378130
  • ENSG00000205403

Symbol
  • IF
  • FI
  • IF
  • KAF
  • AHUS3
  • ARMD13
  • C3BINA
  • C3b-INA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.71
disease
0.66
tissue sample
0.66
biological term
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.28   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.28   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.6
48.2
atrophic macular degeneration
1
1
0
3.6
48.2
1
1
0
3.6
48.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.6
48.2
atrophic macular degeneration
0
3.6
48.2
0
3.6
48.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement factor I
VGNC:579
471271
Mouse
MGI:105937
12630
Rat
RGD:620429
79126
Dog
complement factor I
VGNC:39176
478515
Cow
complement factor I
VGNC:27252
513197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement factor I
Mouse
Rat
Dog
complement factor I
Cow
complement factor I
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05156-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Protein-Protein Interactions (92)
1 – 10 of 92
ECM1
Tbio
Novelty: 0.00518679
p_int: 0.913315227
p_ni: 0.086678974
p_wrong: 0.000005799
Score: 0.51
Data Source: BioPlex,STRINGDB
CFH
Tbio
Novelty: 0.00065547
Score: 0.999
Data Source: Reactome,STRINGDB
C3
Tbio
Novelty: 0.00019115
Score: 0.997
Data Source: Reactome,STRINGDB
CFB
Tchem
Novelty: 0.00102672
Score: 0.983
Data Source: STRINGDB
CD46
Tbio
Novelty: 0.00098341
Score: 0.977
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.969
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.969
Data Source: Reactome,STRINGDB
CFHR3
Tbio
Novelty: 0.01779009
Score: 0.969
Data Source: STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.959
Data Source: STRINGDB
C4BPA
Tbio
Novelty: 0.00319944
Score: 0.955
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  326.28

PubMed score by year
PubTator Score  553.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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