Protein Summary
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associat ...more
- ENST00000394634
- ENSP00000378130
- ENSG00000205403
- IF
- FI
- IF
- KAF
- AHUS3
- ARMD13
- C3BINA
- C3b-INA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.71 | ||
disease | 0.66 | ||
tissue sample | 0.66 | ||
biological term | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 330.29 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 567 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 330.29 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 567 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
ECM1
Novelty: 0.00518679
p_int: 0.913315227
p_ni: 0.086678974
p_wrong: 0.000005799
Score: 0.51
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (11)
Reactome (4)
KEGG (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Regulation of Complement cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complement cascade | ||||
Immune System | ||||
Innate Immune System | ||||
Regulation of Complement cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 1 | 4 | 84.5 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 3 | 84.5 | |||||
3 | 3 | 0 | 1.2 | 81.4 | |||||
atrophic macular degeneration | 1 | 2 | 0 | 2.4 | 71.5 | ||||
2 | 2 | 0 | 1.3 | 71.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 84.5 | |||||
apolipoprotein A 1 measurement | 3 | 84.5 | |||||
0 | 1.2 | 81.4 | |||||
atrophic macular degeneration | 0 | 2.4 | 71.5 | ||||
0 | 1.3 | 71.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | complement factor I | VGNC:579 | 471271 | |||||
Mouse | MGI:105937 | 12630 | ||||||
Rat | RGD:620429 | 79126 | ||||||
Dog | complement factor I | VGNC:39176 | 478515 | |||||
Cow | complement factor I | VGNC:27252 | 513197 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | complement factor I | |||||
Mouse | ||||||
Rat | ||||||
Dog | complement factor I | |||||
Cow | complement factor I | |||||
Publication Statistics
PubMed Score 330.29
PubMed score by year
PubTator Score 553.55
PubTator score by year
Related Publications
Text Mined References (108)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
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