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Tbio
SERPING1
Plasma protease C1 inhibitor

Protein Summary
Description
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278407
  • ENSP00000278407
  • ENSG00000149131
  • ENST00000378323
  • ENSP00000367574
  • ENST00000378324
  • ENSP00000367575

Symbol
  • C1IN
  • C1NH
  • C1IN
  • C1NH
  • HAE1
  • HAE2
  • C1INH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.88
small molecule perturbation
0.84
biological process
0.82
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1679.54   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 514   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1679.54   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.1
neuroticism measurement
5
6
3
6
79.3
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
2
2
2
69.1
platelet count
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.1
neuroticism measurement
3
6
79.3
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
2
69.1
platelet count
1
66.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
serpin family G member 1
703928
Mouse
MGI:894696
12258
Rat
RGD:735225
295703
Dog
serpin family G member 1
VGNC:52042
475966
Horse
serpin family G member 1
VGNC:22861
100066476
Species
Name
OMA
EggNOG
Inparanoid
Macaque
serpin family G member 1
Mouse
Rat
Dog
serpin family G member 1
Horse
serpin family G member 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05155-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Complement cascade
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (160)
1 – 10 of 160
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.998983685
p_ni:  0.001016301
p_wrong:  1.4e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
p_int:  0.99574881
p_ni:  0.00425119
Score:  0.605
Data Source:  BioPlex,STRINGDB
ARFGAP2
Tbio
Family:  Enzyme
Novelty:  0.08758647
p_int:  0.805250756
p_ni:  0.001856545
p_wrong:  0.1928927
Score:  0.379
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.80166982
p_ni:  0.198330177
p_wrong:  3e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
C1R
Tclin
Novelty:  0.00210654
Score:  0.995
Data Source:  Reactome,STRINGDB
C1S
Tchem
Novelty:  0.00043003
Score:  0.994
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.979
Data Source:  STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.975
Data Source:  Reactome,STRINGDB
F12
Tchem
Family:  Enzyme
Novelty:  0.00143881
Score:  0.974
Data Source:  Reactome,STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.973
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1679.54

PubMed score by year
PubTator Score  1161.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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