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Tbio
SERPINA5
Plasma serine protease inhibitor

Protein Summary
Description
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329597
  • ENSP00000333203
  • ENSG00000188488
  • ENST00000553780
  • ENSP00000450837
  • ENST00000554276
  • ENSP00000451610
  • ENST00000554866
  • ENSP00000451126

Symbol
  • PCI
  • PLANH3
  • PROCI
  • PCI
  • PAI3
  • PAI-3
  • PCI-B
  • PROCI
  • PLANH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.85
PubMedID
0.67
small molecule perturbation
0.65
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.42   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.42   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
1
1
41.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
41.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 5
VGNC:10240
100610228
Macaque
serpin family A member 5
702078
Mouse
MGI:107817
268591
Rat
RGD:619817
65051
Cow
serpin family A member 5
VGNC:53954
338050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 5
Macaque
serpin family A member 5
Mouse
Rat
Cow
serpin family A member 5
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05154-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Gene Ontology Terms (33)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
EPSTI1
Tbio
Novelty: 0.07872736
p_int: 0.999999429
p_ni: 5.71e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.00335243
p_int: 0.99997832
p_ni: 0.00002168
Score: 0.172
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.999268525
p_ni: 0.000731409
p_wrong: 6.6e-8
Score: 0.446
Data Source: BioPlex,STRINGDB
HGFAC
Tchem
Family: Enzyme
Novelty: 0.00620243
p_int: 0.994200579
p_ni: 0.000003624
p_wrong: 0.005795797
Score: 0.48
Data Source: BioPlex,STRINGDB
CTAGE5
Tbio
Novelty: 0.04516631
p_int: 0.989121253
p_ni: 0.010856348
p_wrong: 0.000022398
Data Source: BioPlex
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.984977882
p_ni: 0.015022118
Data Source: BioPlex
MIA3
Tbio
Novelty: 0.02784348
p_int: 0.98133989
p_ni: 0.01866011
Score: 0.392
Data Source: BioPlex,STRINGDB
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.924260409
p_ni: 0.075739591
Data Source: BioPlex
CANX
Tbio
Novelty: 0.00087002
p_int: 0.778853539
p_ni: 0.221146461
Score: 0.357
Data Source: BioPlex,STRINGDB
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.769997751
p_ni: 0.230002242
p_wrong: 7e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  561.42

PubMed score by year
PubTator Score  287.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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