Protein Summary
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
- ENST00000317881
- ENSP00000360671
- ENSG00000005022
- ANT2
- T2
- T3
- 2F1
- AAC2
- ANT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
disease perturbation | 0.99 | ||
hub protein | 0.98 | ||
transcription factor perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.27 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.27 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (142)
DKK3
Novelty: 0.00519275
p_int: 0.908663381
p_ni: 0.091336619
Score: 0.219
Data Source: BioPlex,STRINGDB
CCNJL
Novelty: 2.86306774
p_int: 0.752453675
p_ni: 0.247546325
Score: 0.209
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (10)
KEGG (8)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | HIV Infection | ||||
Reactome | Host Interactions of HIV factors | ||||
Reactome | Infectious disease | ||||
Reactome | Interactions of Vpr with host cellular proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
HIV Infection | ||||
Host Interactions of HIV factors | ||||
Infectious disease | ||||
Interactions of Vpr with host cellular proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (9)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 32.7 | |||||
glomerular filtration rate | 1 | 1 | 0 | 6.2 | 5.8 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 32.7 | |||||
glomerular filtration rate | 0 | 6.2 | 5.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | solute carrier family 25 member 5 | 693502 | ||||||
Mouse | MGI:1353496 | 11740 | ||||||
Rat | RGD:620353 | 25176 | ||||||
Dog | solute carrier family 25 member 5 | VGNC:54599 | 492093 | |||||
Cow | solute carrier family 25 member 5 | VGNC:49966 | 282479 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | solute carrier family 25 member 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 25 member 5 | |||||
Cow | solute carrier family 25 member 5 | |||||
Publication Statistics
PubMed Score 134.27
PubMed score by year
PubTator Score 1709.78
PubTator score by year
Related Publications
Text Mined References (53)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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