Tbio SLC25A5 ADP/ATP translocase 2

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc25 Family Of Mitochondrial Transporters / Mitochondrial Nucleotide Transporter Subfamily / Adp/atp Translocase 2

Protein Summary

Description

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P05141
• B2RCV1
• O43350

Gene Name

• SLC25A5

Ensembl ID

• ENST00000317881
• ENSP00000360671
• ENSG00000005022

Symbol

• ANT2
• T2
• T3
• 2F1
• AAC2
• ANT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
disease perturbation	0.99
hub protein	0.98
transcription factor perturbation	0.96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.6   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.6   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (19)

Reactome (10)

KEGG (8)

WikiPathways (1)

Disease (R-HSA-1643685)

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Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	HIV Infection	256 targets	R-HSA-162906
Reactome	Host Interactions of HIV factors	153 targets	R-HSA-162909
Reactome	Infectious disease	408 targets	R-HSA-5663205
Reactome	Interactions of Vpr with host cellular proteins	37 targets	R-HSA-176033

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
HIV Infection	256 targets	R-HSA-162906
Host Interactions of HIV factors	153 targets	R-HSA-162909
Infectious disease	408 targets	R-HSA-5663205
Interactions of Vpr with host cellular proteins	37 targets	R-HSA-176033

Gene Ontology Terms (19)

Functions (4)

Components (9)

Processes (6)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP:ADP antiporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
adenine transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (142)

Explore Interacting Targets

1 – 10 of 142

• See Interactions on String-DB

DKK3

Tbio

Novelty: 0.00427648

p_int: 0.908663381

p_ni: 0.091336619

Score: 0.219

Data Source: BioPlex,STRINGDB

OSTM1

Tbio

Novelty: 0.04716423

p_int: 0.824094349

p_ni: 0.175905651

Data Source: BioPlex

CCNJL

Tdark

p_int: 0.752453675

p_ni: 0.247546325

Score: 0.209

Data Source: BioPlex,STRINGDB

SLC25A4

Tbio

Family: Transporter

Novelty: 0.01081101

Score: 0.98

Data Source: STRINGDB

MMS19

Tbio

Novelty: 0.01981677

Score: 0.966

Data Source: STRINGDB

PPIF

Tchem

Family: Enzyme

Novelty: 0.00194474

Score: 0.96

Data Source: STRINGDB

VDAC2

Tchem

Novelty: 0.00835655

Score: 0.954

Data Source: STRINGDB

CIAO2B

Tbio

Novelty: 0.11934165

Score: 0.947

Data Source: STRINGDB

ATP5F1B

Tbio

Family: Enzyme

Novelty: 0.02087315

Score: 0.946

Data Source: STRINGDB

CIAO1

Tbio

Novelty: 0.04042313

Score: 0.944

Data Source: STRINGDB

Publication Statistics

PubMed Score  103.60

PubMed score by year

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PubTator Score  1709.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSF

1-70

WRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTR

70-140

LAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHI

140-210

VISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR

210-280

GMGGAFVLVLYDEIKKYT

280-298

MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Find similar targets by:

Uniprot Keyword

Acetylation
Chromosome partition
Complete proteome
Direct protein sequencing
Host-virus interaction
Membrane
Methylation
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein