Tbio SLC25A5 ADP/ATP translocase 2

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc25 Family Of Mitochondrial Transporters / Mitochondrial Nucleotide Transporter Subfamily / Adp/atp Translocase 2

Protein Summary

Description

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P05141
• B2RCV1
• O43350

Gene Name

• SLC25A5

Ensembl ID

• ENST00000317881
• ENSP00000360671
• ENSG00000005022

Symbol

• ANT2
• T2
• T3
• 2F1
• AAC2
• ANT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
disease perturbation	0.99
hub protein	0.98
transcription factor perturbation	0.96

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.78   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.78   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	1	1	0	6.2	1.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	0	6.2	1.3

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 25 member 5		693502
Mouse	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5	MGI:1353496	11740
Rat	solute carrier family 25 member 5	RGD:620353	25176
Dog	solute carrier family 25 member 5	VGNC:54599	492093
Cow	solute carrier family 25 member 5	VGNC:49966	282479

Species	Name	OMA	EggNOG	Inparanoid
Macaque	solute carrier family 25 member 5
Mouse	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
Rat	solute carrier family 25 member 5
Dog	solute carrier family 25 member 5
Cow	solute carrier family 25 member 5

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P05141-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)

Reactome (10)

KEGG (8)

WikiPathways (1)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	HIV Infection	256 targets	R-HSA-162906
Reactome	Host Interactions of HIV factors	153 targets	R-HSA-162909
Reactome	Infectious disease	408 targets	R-HSA-5663205
Reactome	Interactions of Vpr with host cellular proteins	37 targets	R-HSA-176033

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
HIV Infection	256 targets	R-HSA-162906
Host Interactions of HIV factors	153 targets	R-HSA-162909
Infectious disease	408 targets	R-HSA-5663205
Interactions of Vpr with host cellular proteins	37 targets	R-HSA-176033

Gene Ontology Terms (19)

Functions (4)

Components (9)

Processes (6)

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1 – 4 of 4

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP:ADP antiporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
adenine transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (142)

Explore Interacting Targets

1 – 10 of 142

• See Interactions on String-DB

DKK3

Tbio

Novelty: 0.00519275

p_int: 0.908663381

p_ni: 0.091336619

Score: 0.219

Data Source: BioPlex,STRINGDB

OSTM1

Tbio

Novelty: 0.03033192

p_int: 0.824094349

p_ni: 0.175905651

Data Source: BioPlex

CCNJL

Tdark

Novelty: 2.86306774

p_int: 0.752453675

p_ni: 0.247546325

Score: 0.209

Data Source: BioPlex,STRINGDB

SLC25A4

Tbio

Family: Transporter

Novelty: 0.01250865

Score: 0.98

Data Source: STRINGDB

MMS19

Tbio

Novelty: 0.01978769

Score: 0.966

Data Source: STRINGDB

PPIF

Tchem

Family: Enzyme

Novelty: 0.00147732

Score: 0.96

Data Source: STRINGDB

VDAC2

Tchem

Novelty: 0.00575936

Score: 0.954

Data Source: STRINGDB

CIAO2B

Tbio

Novelty: 0.09725962

Score: 0.947

Data Source: STRINGDB

ATP5F1B

Tbio

Family: Enzyme

Novelty: 0.01053177

Score: 0.946

Data Source: STRINGDB

CIAO1

Tbio

Novelty: 0.03999673

Score: 0.944

Data Source: STRINGDB

Publication Statistics

PubMed Score  131.78

PubMed score by year

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PubTator Score  1709.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Chromosome partition
Complete proteome
Direct protein sequencing
Host-virus interaction
Membrane
Methylation
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein

GWAS Trait Find Similar Targets

glomerular filtration rate