You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SLC25A5
ADP/ATP translocase 2

Protein Summary
Description
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317881
  • ENSP00000360671
  • ENSG00000005022

Symbol
  • ANT2
  • T2
  • T3
  • 2F1
  • AAC2
  • ANT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.99
hub protein
0.98
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.27   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.27   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.908663381
p_ni:  0.091336619
Score:  0.219
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.824094349
p_ni:  0.175905651
Data Source:  BioPlex
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.752453675
p_ni:  0.247546325
Score:  0.209
Data Source:  BioPlex,STRINGDB
SLC25A4
Tbio
Family:  Transporter
Novelty:  0.01250865
Score:  0.98
Data Source:  STRINGDB
MMS19
Tbio
Novelty:  0.01978769
Score:  0.966
Data Source:  STRINGDB
PPIF
Tchem
Family:  Enzyme
Novelty:  0.00147732
Score:  0.96
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.954
Data Source:  STRINGDB
CIAO2B
Tbio
Novelty:  0.09725962
Score:  0.947
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.946
Data Source:  STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Reactome
Interactions of Vpr with host cellular proteins
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Infectious disease
Interactions of Vpr with host cellular proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
32.7
glomerular filtration rate
1
1
0
6.2
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
32.7
glomerular filtration rate
0
6.2
5.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 5
693502
Mouse
MGI:1353496
11740
Rat
RGD:620353
25176
Dog
solute carrier family 25 member 5
VGNC:54599
492093
Cow
solute carrier family 25 member 5
VGNC:49966
282479
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 5
Mouse
Rat
Dog
solute carrier family 25 member 5
Cow
solute carrier family 25 member 5
Publication Statistics
PubMed Score 134.27
PubMed score by year
PubTator Score 1709.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title