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Tchem
PRKCG
Protein kinase C gamma type

Protein Classes
Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263431
  • ENSP00000263431
  • ENSG00000126583

Symbol
  • PKCG
  • PKCC
  • PKCG
  • SCA14
  • PKCI(3)
  • PKCgamma
  • PKC-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
hub protein
0.97
biological process
0.94
pathway
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.25   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 555   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.25   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 555   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C gamma
VGNC:12066
456276
Macaque
protein kinase C gamma
720263
Mouse
MGI:97597
18752
Rat
RGD:3397
24681
Dog
protein kinase C gamma type
484316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C gamma
Macaque
protein kinase C gamma
Mouse
Rat
Dog
protein kinase C gamma type
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05129-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (131)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
Calmodulin induced events
Reactome
DAG and IP3 signaling
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca-dependent events
CaM pathway
Calmodulin induced events
DAG and IP3 signaling
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (245)
1 – 10 of 245
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
p_int: 0.999999999
Score: 0.937
Data Source: BioPlex,STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.98
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.972
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.956
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.942
Data Source: STRINGDB
PICK1
Tbio
Novelty: 0.0058265
Score: 0.941
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.939
Data Source: Reactome,STRINGDB
DVL2
Tbio
Novelty: 0.00833084
Score: 0.938
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.933
Data Source: STRINGDB
GRIA3
Tclin
Family: IC
Novelty: 0.00584546
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  349.25

PubMed score by year
PubTator Score  175.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer