Tbio SERPINB2 Plasminogen activator inhibitor 2

Protein Summary

Description

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Uniprot Accession IDs

• P05120
• Q96E96
• PAI-2

Gene Name

• SERPINB2

Ensembl ID

• ENST00000299502
• ENSP00000299502
• ENSG00000197632
• ENST00000457692
• ENSP00000401645

Symbol

• PAI2
• PLANH2
• PAI
• PAI2
• PAI-2
• PLANH2
• HsT1201

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
disease	0.78
small molecule perturbation	0.76
virus perturbation	0.72
interacting protein	0.7

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Plasminogen Activator Inhibitor 2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Plasminogen Activator Inhibitor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.43   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 419   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.43   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0