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Tbio
HMGN1
Non-histone chromosomal protein HMG-14

Protein Summary
Description
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380749
  • ENSP00000370125
  • ENSG00000205581

Symbol
  • HMG14
  • HMG14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.98
kinase perturbation
0.95
transcription factor perturbation
0.91
kinase
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.89   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.89   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
3
76.5
apolipoprotein B measurement
1
1
1
66.8
serum alanine aminotransferase measurement
1
1
1
57.3
platelet crit
2
2
2
53.2
intelligence
2
2
0
5.5
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
76.5
apolipoprotein B measurement
1
66.8
serum alanine aminotransferase measurement
1
57.3
platelet crit
2
53.2
intelligence
0
5.5
50.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group nucleosome binding domain 1
458552
Mouse
MGI:96120
15312
Rat
RGD:6494054
100911295
Dog
high mobility group nucleosome binding domain 1
608119
Horse
high mobility group nucleosome binding domain 1 [Source:HGNC Symbol;Acc:HGNC:4984]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group nucleosome binding domain 1
Mouse
Rat
Dog
high mobility group nucleosome binding domain 1
Horse
high mobility group nucleosome binding domain 1 [Source:HGNC Symbol;Acc:HGNC:4984]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P05114-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Nucleotide Excision Repair
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (115)
1 – 10 of 115
HIST1H4G
Tdark
Novelty:  1.72429907
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.288
Data Source:  BioPlex,STRINGDB
KLHL36
Tdark
Novelty:  1.4153425
p_int:  0.999995913
p_ni:  0.000004086
p_wrong:  1e-9
Data Source:  BioPlex
FAM216A
Tdark
Novelty:  0.74863593
p_int:  0.999614443
p_ni:  0.000376755
p_wrong:  0.000008802
Data Source:  BioPlex
RSF1
Tbio
Family:  Epigenetic
Novelty:  0.0155058
p_int:  0.995324742
p_ni:  0.000002749
p_wrong:  0.004672509
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.982869791
p_ni:  0.017128648
p_wrong:  0.000001561
Score:  0.263
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.966508082
p_ni:  0.03349177
p_wrong:  1.48e-7
Data Source:  BioPlex
XPC
Tbio
Novelty:  0.00775175
p_int:  0.95718224
p_ni:  0.042817757
p_wrong:  3e-9
Score:  0.241
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.908967393
p_ni:  0.091032607
Score:  0.202
Data Source:  BioPlex,STRINGDB
H2AFY
Tbio
Novelty:  0.01150729
p_int:  0.756197573
p_ni:  0.243802386
p_wrong:  4.1e-8
Data Source:  BioPlex
XAB2
Tbio
Novelty:  0.04104647
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  223.89

PubMed score by year
PubTator Score  103.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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