Tclin IL5 Interleukin-5

Protein Summary

Description

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P05113
• Q13840
• IL-5

Gene Name

• IL5

Ensembl ID

• ENST00000231454
• ENSP00000231454
• ENSG00000113525

Symbol

• EDF
• TRF
• IL-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
biological term	0.94
gene perturbation	0.94
biological process	0.93
phenotype	0.91

Protein Classes

DTO Classes

Interleukin-5 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6413.72   (req: < 5)

Gene RIFs: 170   (req: <= 3)

Antibodies: 690   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6413.72   (req: >= 5)

Gene RIFs: 170   (req: > 3)

Antibodies: 690   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2