Protein Summary
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
- ENST00000231454
- ENSP00000231454
- ENSG00000113525
- EDF
- TRF
- IL-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
biological term | 0.94 | ||
gene perturbation | 0.94 | ||
biological process | 0.93 | ||
phenotype | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5711.32 (req: < 5)
Gene RIFs: 139 (req: <= 3)
Antibodies: 690 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5711.32 (req: >= 5)
Gene RIFs: 139 (req: > 3)
Antibodies: 690 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (334)
Nearest Tclin Targets
Pathways (62)
Reactome (12)
KEGG (13)
PathwayCommons (15)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Immune System | ||||
Reactome | Interleukin receptor SHC signaling | ||||
Reactome | Interleukin-2 family signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Immune System | ||||
Interleukin receptor SHC signaling | ||||
Interleukin-2 family signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (5)
Components (2)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 6 | 11 | 12 | 7.1 | 99.8 | ||||
eosinophil percentage of leukocytes | 2 | 6 | 8 | 99.1 | |||||
fibrinogen measurement | 4 | 3 | 4 | 97 | |||||
8 | 11 | 1 | 1.1 | 96.4 | |||||
3 | 3 | 1 | 1.2 | 96.2 | |||||
Items per page:
1 – 5 of 44
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 12 | 7.1 | 99.8 | ||||
eosinophil percentage of leukocytes | 8 | 99.1 | |||||
fibrinogen measurement | 4 | 97 | |||||
1 | 1.1 | 96.4 | |||||
1 | 1.2 | 96.2 | |||||
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IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 5 | VGNC:13513 | 743963 | |||||
Macaque | interleukin 5 | 710622 | ||||||
Mouse | MGI:96557 | 16191 | ||||||
Rat | RGD:2900 | 24497 | ||||||
Dog | interleukin 5 | VGNC:41990 | 403790 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 5 | |||||
Macaque | interleukin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 5 | |||||
Publication Statistics
PubMed Score 5711.32
PubMed score by year
PubTator Score 2575.13
PubTator score by year
Related Publications
Text Mined References (213)
GeneRif Annotations (139)
Items per page:
0 of 0
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