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Tclin
IL5
Interleukin-5

Protein Summary
Description
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231454
  • ENSP00000231454
  • ENSG00000113525

Symbol
  • EDF
  • TRF
  • IL-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological term
0.94
gene perturbation
0.94
biological process
0.93
phenotype
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5711.32   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 690   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5711.32   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 690   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
IL5RA
Tclin
Novelty:  0.01418963
Score:  0.997
Data Source:  Reactome,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.995
Data Source:  STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.989
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.988
Data Source:  STRINGDB
IL3
Tbio
Novelty:  0.0002336
Score:  0.987
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.972
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.972
Data Source:  Reactome,STRINGDB
CSF2RB
Tclin
Novelty:  0.02093804
Score:  0.968
Data Source:  Reactome,STRINGDB
IL2RA
Tclin
Novelty:  0.0007607
Score:  0.965
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-2 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-2 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
11
12
7.1
99.8
eosinophil percentage of leukocytes
2
6
8
99.1
fibrinogen measurement
4
3
4
97
8
11
1
1.1
96.4
3
3
1
1.2
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
12
7.1
99.8
eosinophil percentage of leukocytes
8
99.1
fibrinogen measurement
4
97
1
1.1
96.4
1
1.2
96.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 5
VGNC:13513
743963
Macaque
interleukin 5
710622
Mouse
MGI:96557
16191
Rat
RGD:2900
24497
Dog
interleukin 5
VGNC:41990
403790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 5
Macaque
interleukin 5
Mouse
Rat
Dog
interleukin 5
Publication Statistics
PubMed Score 5711.32
PubMed score by year
PubTator Score 2575.13
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title