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Tclin
IL5
Interleukin-5

Protein Classes
Protein Summary
Description
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231454
  • ENSP00000231454
  • ENSG00000113525

Symbol
  • EDF
  • TRF
  • IL-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological term
0.94
gene perturbation
0.94
biological process
0.93
phenotype
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5604.22   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 690   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5604.22   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 690   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
mepolizumab
no chemical structure image available
reslizumab
no chemical structure image available
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
78.9
1
1
0
1.2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
78.9
0
1.2
76.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (62)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-2 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-2 family signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (334)
1 – 10 of 334
IL5RA
Tclin
Novelty: 0.01418963
Score: 0.997
Data Source: Reactome,STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.995
Data Source: STRINGDB
CSF2
Tbio
Novelty: 0.00010437
Score: 0.989
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.988
Data Source: STRINGDB
IL3
Tbio
Novelty: 0.0002336
Score: 0.987
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.972
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.972
Data Source: Reactome,STRINGDB
CSF2RB
Tclin
Novelty: 0.02093804
Score: 0.968
Data Source: Reactome,STRINGDB
IL2RA
Tclin
Novelty: 0.0007607
Score: 0.965
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  5604.22

PubMed score by year
PubTator Score  2575.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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