Protein Classes
Protein Summary
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
- ENST00000231454
- ENSP00000231454
- ENSG00000113525
- EDF
- TRF
- IL-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
biological term | 0.94 | ||
gene perturbation | 0.94 | ||
biological process | 0.93 | ||
phenotype | 0.91 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5604.22 (req: < 5)
Gene RIFs: 139 (req: <= 3)
Antibodies: 690 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5604.22 (req: >= 5)
Gene RIFs: 139 (req: > 3)
Antibodies: 690 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 78.9 | |||||
1 | 1 | 0 | 1.2 | 76.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 78.9 | |||||
0 | 1.2 | 76.2 | |||||
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (62)
Reactome (12)
KEGG (13)
PathwayCommons (15)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Immune System | ||||
Reactome | Interleukin receptor SHC signaling | ||||
Reactome | Interleukin-2 family signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Immune System | ||||
Interleukin receptor SHC signaling | ||||
Interleukin-2 family signaling | ||||
Gene Ontology Terms (19)
Functions (5)
Components (2)
Processes (12)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (334)
1 – 10 of 334
IL5RA
Novelty: 0.01418963
Score: 0.997
Data Source: Reactome,STRINGDB
IL2
Novelty: 0.00003129
Score: 0.995
Data Source: STRINGDB
CSF2
Novelty: 0.00010437
Score: 0.989
Data Source: STRINGDB
GATA3
Family: TF
Novelty: 0.00071141
Score: 0.988
Data Source: STRINGDB
IL3
Novelty: 0.0002336
Score: 0.987
Data Source: STRINGDB
STAT5B
Family: TF
Novelty: 0.00074178
Score: 0.972
Data Source: Reactome,STRINGDB
STAT5A
Family: TF
Novelty: 0.00074026
Score: 0.972
Data Source: Reactome,STRINGDB
CSF2RB
Novelty: 0.02093804
Score: 0.968
Data Source: Reactome,STRINGDB
IL2RA
Novelty: 0.0007607
Score: 0.965
Data Source: STRINGDB
IL4
Novelty: 0.00005852
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score 5604.22
PubMed score by year
PubTator Score 2575.13
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword