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Tbio
IL4
Interleukin-4

Protein Summary
Description
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity). The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231449
  • ENSP00000231449
  • ENSG00000113520
  • ENST00000350025
  • ENSP00000325190

Symbol
  • BSF1
  • IL-4
  • BCGF1
  • BSF-1
  • BCGF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
co-expressed gene
0.89
disease
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17041.12   (req: < 5)
Gene RIFs: 779   (req: <= 3)
Antibodies: 1683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17041.12   (req: >= 5)
Gene RIFs: 779   (req: > 3)
Antibodies: 1683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (685)
IL4R
Tclin
Novelty:  0.00359183
Score:  0.999
Data Source:  Reactome,STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.997
Data Source:  Reactome,STRINGDB
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.996
Data Source:  Reactome,STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.996
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.992
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.992
Data Source:  STRINGDB
IL13RA1
Tbio
Novelty:  0.03308775
Score:  0.992
Data Source:  Reactome,STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.991
Data Source:  STRINGDB
CCL2
Tchem
Novelty:  0.00010958
Score:  0.991
Data Source:  STRINGDB
IL18
Tbio
Novelty:  0.00022844
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
1 – 2 of 2
Pathways (56)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
11
1
1.1
97.5
childhood onset asthma
3
4
0
1.2
96.9
eosinophil count
2
3
3
95.1
5
6
0
1.1
94.3
5
5
2
1.1
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97.5
childhood onset asthma
0
1.2
96.9
eosinophil count
3
95.1
0
1.1
94.3
2
1.1
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 4
VGNC:4046
449565
Macaque
interleukin 4
574281
Mouse
MGI:96556
16189
Rat
RGD:2898
287287
Dog
interleukin 4
VGNC:41987
403785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 4
Macaque
interleukin 4
Mouse
Rat
Dog
interleukin 4
Publication Statistics
PubMed Score 17041.12
PubMed score by year
PubTator Score 6709.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title