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Tbio
INHA
Inhibin alpha chain

Protein Summary
Description
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243786
  • ENSP00000243786
  • ENSG00000123999
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
protein domain
0.85
biological term
0.84
phenotype
0.77
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.85   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 673   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.85   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 673   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (42)
Glycoprotein hormones (R-HSA-209822)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycoprotein hormones
Reactome
Metabolism of proteins
Reactome
Peptide hormone biosynthesis
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Glycoprotein hormones
Metabolism of proteins
Peptide hormone biosynthesis
Peptide hormone metabolism
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (57)
1 – 10 of 57
PDIA3
Tbio
Family: Enzyme
Novelty: 0.00285939
p_int: 0.997895438
p_ni: 0.002104562
Score: 0.54
Data Source: BioPlex,STRINGDB
CALR
Tbio
Novelty: 0.0004479
p_int: 0.994813064
p_ni: 0.005186936
Score: 0.513
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.929269766
p_ni: 0.070730234
Data Source: BioPlex
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
p_int: 0.75476235
p_ni: 0.197501448
p_wrong: 0.047736202
Score: 0.534
Data Source: BioPlex,STRINGDB
INHBC
Tbio
Novelty: 0.06055226
Score: 0.961
Data Source: Reactome,STRINGDB
INHBB
Tbio
Novelty: 0.0154773
Score: 0.954
Data Source: Reactome,STRINGDB
INHBA
Tbio
Novelty: 0.00657844
Score: 0.951
Data Source: Reactome,STRINGDB
FSHB
Tbio
Novelty: 0.00510815
Score: 0.938
Data Source: STRINGDB
INHBE
Tbio
Novelty: 0.07526145
Score: 0.92
Data Source: Reactome,STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  587.85

PubMed score by year
PubTator Score  244.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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