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Tbio
S100A8
Protein S100-A8

Protein Summary
Description
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368732
  • ENSP00000357721
  • ENSG00000143546
  • ENST00000368733
  • ENSP00000357722

Symbol
  • CAGA
  • CFAG
  • MRP8
  • P8
  • MIF
  • NIF
  • CAGA
  • CFAG
  • CGLA
  • L1Ag
  • MRP8
  • CP-10
  • MA387
  • 60B8AG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.97
biological process
0.96
small molecule perturbation
0.95
molecular function
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1373.75   (req: < 5)
Gene RIFs: 350   (req: <= 3)
Antibodies: 1141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1373.75   (req: >= 5)
Gene RIFs: 350   (req: > 3)
Antibodies: 1141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0