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Tbio
S100A8
Protein S100-A8

Protein Summary
Description
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368732
  • ENSP00000357721
  • ENSG00000143546
  • ENST00000368733
  • ENSP00000357722

Symbol
  • CAGA
  • CFAG
  • MRP8
  • P8
  • MIF
  • NIF
  • CAGA
  • CFAG
  • CGLA
  • L1Ag
  • MRP8
  • CP-10
  • MA387
  • 60B8AG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.97
biological process
0.96
small molecule perturbation
0.95
molecular function
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1056.82   (req: < 5)
Gene RIFs: 247   (req: <= 3)
Antibodies: 1141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1056.82   (req: >= 5)
Gene RIFs: 247   (req: > 3)
Antibodies: 1141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metal sequestration by antimicrobial proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Metal sequestration by antimicrobial proteins
Neutrophil degranulation
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (159)
1 – 10 of 159
SMTNL2
Tdark
Novelty: 0.33805653
p_int: 0.999721302
p_ni: 0.000259638
p_wrong: 0.00001906
Score: 0.188
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.96618469
p_ni: 0.03381531
Data Source: BioPlex
DPH6
Tbio
Family: Enzyme
Novelty: 0.15211179
p_int: 0.959965641
p_ni: 0.040034359
Score: 0.221
Data Source: BioPlex,STRINGDB
EFHD1
Tbio
Novelty: 0.00808906
p_int: 0.778609402
p_ni: 0.001933117
p_wrong: 0.219457481
Score: 0.197
Data Source: BioPlex,STRINGDB
CCNYL1
Tdark
Novelty: 0.45350824
p_int: 0.757487725
p_ni: 0.242512272
p_wrong: 3e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
S100A9
Tbio
Novelty: 0.00185141
Score: 0.999
Data Source: Reactome,STRINGDB
S100A12
Tbio
Novelty: 0.0027286
Score: 0.985
Data Source: STRINGDB
LY96
Tchem
Novelty: 0.00123253
Score: 0.952
Data Source: Reactome,STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.951
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  1056.82

PubMed score by year
PubTator Score  1404.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer