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Tclin
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial

Protein Summary
Description
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268053
  • ENSP00000268053
  • ENSG00000140459
  • ENST00000358632
  • ENSP00000351455

Symbol
  • CYP11A
  • CYP11A
  • CYPXIA1
  • P450SCC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.97
chemical
0.92
virus perturbation
0.88
molecular function
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 992.99   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 992.99   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
FDX1
Tbio
Novelty:  0.00124491
Score:  0.998
Data Source:  Reactome,STRINGDB
STAR
Tbio
Novelty:  0.0012662
Score:  0.994
Data Source:  STRINGDB
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
Score:  0.993
Data Source:  STRINGDB
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.987
Data Source:  STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
Score:  0.978
Data Source:  Reactome,STRINGDB
CYP17A1
Tclin
Family:  Enzyme
Novelty:  0.00065091
Score:  0.953
Data Source:  STRINGDB
CYP21A2
Tchem
Family:  Enzyme
Novelty:  0.00110959
Score:  0.944
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.937
Data Source:  STRINGDB
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
Score:  0.927
Data Source:  STRINGDB
CYP7B1
Tbio
Family:  Enzyme
Novelty:  0.01164653
Score:  0.914
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Disease
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
1
2
2
65.4
apolipoprotein A 1 measurement
1
1
1
56
high density lipoprotein cholesterol measurement
2
1
2
55.2
1
1
0
1.2
47.7
Cleft palate
1
1
0
1.2
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
2
65.4
apolipoprotein A 1 measurement
1
56
high density lipoprotein cholesterol measurement
2
55.2
0
1.2
47.7
Cleft palate
0
1.2
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cholesterol side-chain cleavage enzyme, mitochondrial
708065
Mouse
MGI:88582
13070
Rat
RGD:69325
29680
Dog
cytochrome P450 family 11 subfamily A member 1
VGNC:50329
478365
Horse
cytochrome P450 family 11 subfamily A member 1
VGNC:50388
100034229
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cholesterol side-chain cleavage enzyme, mitochondrial
Mouse
Rat
Dog
cytochrome P450 family 11 subfamily A member 1
Horse
cytochrome P450 family 11 subfamily A member 1
Publication Statistics
PubMed Score 992.99
PubMed score by year
PubTator Score 553.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title