CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial
Protein Summary
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
- ENST00000268053
- ENSP00000268053
- ENSG00000140459
- ENST00000358632
- ENSP00000351455
- CYP11A
- CYP11A
- CYPXIA1
- P450SCC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
biological process | 0.97 | ||
chemical | 0.92 | ||
virus perturbation | 0.88 | ||
molecular function | 0.81 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 973.69 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 398 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 973.69 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 398 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cholesterol side-chain cleavage enzyme, mitochondrial | 708065 | ||||||
Mouse | MGI:88582 | 13070 | ||||||
Rat | RGD:69325 | 29680 | ||||||
Dog | cytochrome P450 family 11 subfamily A member 1 | VGNC:50329 | 478365 | |||||
Horse | cytochrome P450 family 11 subfamily A member 1 | VGNC:50388 | 100034229 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cholesterol side-chain cleavage enzyme, mitochondrial | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 11 subfamily A member 1 | |||||
Horse | cytochrome P450 family 11 subfamily A member 1 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (27)
Reactome (13)
KEGG (6)
UniProt (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | ||||
Disease | ||||
Diseases of metabolism | ||||
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (94)
1 – 10 of 94
FDX1
Novelty: 0.00124491
Score: 0.998
Data Source: Reactome,STRINGDB
STAR
Novelty: 0.0012662
Score: 0.994
Data Source: STRINGDB
HSD3B1
Family: Enzyme
Novelty: 0.0019271
Score: 0.993
Data Source: STRINGDB
HSD3B2
Family: Enzyme
Novelty: 0.00711552
Score: 0.987
Data Source: STRINGDB
FDXR
Family: Enzyme
Novelty: 0.00171588
Score: 0.978
Data Source: Reactome,STRINGDB
CYP17A1
Family: Enzyme
Novelty: 0.00065091
Score: 0.953
Data Source: STRINGDB
CYP21A2
Family: Enzyme
Novelty: 0.00110959
Score: 0.944
Data Source: STRINGDB
STS
Family: Enzyme
Novelty: 0.00324549
Score: 0.937
Data Source: STRINGDB
SULT2B1
Family: Enzyme
Novelty: 0.02652128
Score: 0.927
Data Source: STRINGDB
CYP7B1
Family: Enzyme
Novelty: 0.01164653
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score 973.69
PubMed score by year
PubTator Score 553.78
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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