CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial
Protein Summary
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
- ENST00000268053
- ENSP00000268053
- ENSG00000140459
- ENST00000358632
- ENSP00000351455
- CYP11A
- CYP11A
- CYPXIA1
- P450SCC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
biological process | 0.97 | ||
chemical | 0.92 | ||
virus perturbation | 0.88 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 992.99 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 398 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 992.99 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 398 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (94)
Nearest Tclin Targets
Pathways (27)
Reactome (13)
KEGG (6)
UniProt (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | ||||
Disease | ||||
Diseases of metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cups of coffee per day measurement | 1 | 2 | 2 | 65.4 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 56 | |||||
high density lipoprotein cholesterol measurement | 2 | 1 | 2 | 55.2 | |||||
1 | 1 | 0 | 1.2 | 47.7 | |||||
Cleft palate | 1 | 1 | 0 | 1.2 | 47.7 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cups of coffee per day measurement | 2 | 65.4 | |||||
apolipoprotein A 1 measurement | 1 | 56 | |||||
high density lipoprotein cholesterol measurement | 2 | 55.2 | |||||
0 | 1.2 | 47.7 | |||||
Cleft palate | 0 | 1.2 | 47.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cholesterol side-chain cleavage enzyme, mitochondrial | 708065 | ||||||
Mouse | MGI:88582 | 13070 | ||||||
Rat | RGD:69325 | 29680 | ||||||
Dog | cytochrome P450 family 11 subfamily A member 1 | VGNC:50329 | 478365 | |||||
Horse | cytochrome P450 family 11 subfamily A member 1 | VGNC:50388 | 100034229 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cholesterol side-chain cleavage enzyme, mitochondrial | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 11 subfamily A member 1 | |||||
Horse | cytochrome P450 family 11 subfamily A member 1 | |||||
Publication Statistics
PubMed Score 992.99
PubMed score by year
PubTator Score 553.78
PubTator score by year
Related Publications
Text Mined References (139)
GeneRif Annotations (82)
Items per page:
0 of 0
PMID | Year | Title |
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