CYP17A1
Steroid 17-alpha-hydroxylase/17,20 lyase
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 0.93 | ||
biological process | 0.9 | ||
disease | 0.79 | ||
molecular function | 0.76 | ||
cellular component | 0.72 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Androgen biosynthesis | ||||
Reactome | Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glucocorticoid biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Androgen biosynthesis | ||||
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) | ||||
Disease | ||||
Diseases of metabolism | ||||
Glucocorticoid biosynthesis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 4 | 5 | 94.2 | |||||
6 | 4 | 3 | 1.1 | 91.7 | |||||
12 | 8 | 3 | 1.1 | 91.1 | |||||
body mass index | 5 | 4 | 6 | 84.6 | |||||
monocyte count | 2 | 2 | 2 | 84.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 94.2 | |||||
3 | 1.1 | 91.7 | |||||
3 | 1.1 | 91.1 | |||||
body mass index | 6 | 84.6 | |||||
monocyte count | 2 | 84.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 17, subfamily A, polypeptide 1 | 450141 | ||||||
Macaque | cytochrome P450c17 | 678693 | ||||||
Mouse | MGI:88586 | 13074 | ||||||
Rat | RGD:2456 | 25146 | ||||||
Dog | cytochrome P450 family 17 subfamily A member 1 | VGNC:50330 | 477807 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 17, subfamily A, polypeptide 1 | |||||
Macaque | cytochrome P450c17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 17 subfamily A member 1 | |||||
PMID | Year | Title |
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