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Tclin
CYP17A1
Steroid 17-alpha-hydroxylase/17,20 lyase

Protein Summary
Description
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369887
  • ENSP00000358903
  • ENSG00000148795

Symbol
  • CYP17
  • S17AH
  • CPT7
  • CYP17
  • S17AH
  • P450C17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.93
biological process
0.9
disease
0.79
molecular function
0.76
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1561.78   (req: < 5)
Gene RIFs: 311   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1561.78   (req: >= 5)
Gene RIFs: 311   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 477
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Active Ligands (477)
1 – 10 of 477
CHEMBL295698
chemical structure image
CHEMBL1172882
chemical structure image
CHEMBL1173260
chemical structure image
CHEMBL305220
chemical structure image
CHEMBL307160
chemical structure image
CHEMBL78322
chemical structure image
CHEMBL362968,CHEMBL460178
chemical structure image
CHEMBL2333326
chemical structure image
CHEMBL2333336
chemical structure image
CHEMBL1083652
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
76.1
1
1
0
1.1
68.7
2
1
2
68.2
worry measurement
1
1
1
60.6
neuroticism measurement
1
1
1
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
76.1
0
1.1
68.7
2
68.2
worry measurement
1
60.6
neuroticism measurement
1
49.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 17, subfamily A, polypeptide 1
450141
Macaque
cytochrome P450c17
678693
Mouse
MGI:88586
13074
Rat
RGD:2456
25146
Dog
cytochrome P450 family 17 subfamily A member 1
VGNC:50330
477807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 17, subfamily A, polypeptide 1
Macaque
cytochrome P450c17
Mouse
Rat
Dog
cytochrome P450 family 17 subfamily A member 1
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05093-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glucocorticoid biosynthesis
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Disease
Diseases of metabolism
Glucocorticoid biosynthesis
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.993
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.989
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.986
Data Source: STRINGDB
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
Score: 0.98
Data Source: STRINGDB
SRD5A2
Tclin
Family: Enzyme
Novelty: 0.00281044
Score: 0.973
Data Source: STRINGDB
SRD5A1
Tclin
Family: Enzyme
Novelty: 0.00987219
Score: 0.972
Data Source: STRINGDB
AKR1C3
Tchem
Family: Enzyme
Novelty: 0.00257785
Score: 0.966
Data Source: STRINGDB
HSD17B2
Tchem
Family: Enzyme
Novelty: 0.00960865
Score: 0.96
Data Source: STRINGDB
CYP11A1
Tclin
Family: Enzyme
Novelty: 0.00096368
Score: 0.953
Data Source: STRINGDB
CYP11B1
Tclin
Family: Enzyme
Novelty: 0.00195229
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  1561.78

PubMed score by year
PubTator Score  1029.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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