Tclin CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase

Protein Summary

Description

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05093
• Q5TZV7

Gene Name

• CYP17A1

Ensembl ID

• ENST00000369887
• ENSP00000358903
• ENSG00000148795

Symbol

• CYP17
• S17AH
• CPT7
• CYP17
• S17AH
• P450C17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.93
biological process	0.9
disease	0.79
molecular function	0.76
cellular component	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1704.06   (req: < 5)

Gene RIFs: 311   (req: <= 3)

Antibodies: 545   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1704.06   (req: >= 5)

Gene RIFs: 311   (req: > 3)

Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 580

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7