CYP17A1
Steroid 17-alpha-hydroxylase/17,20 lyase
Protein Summary
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
- ENST00000369887
- ENSP00000358903
- ENSG00000148795
- CYP17
- S17AH
- CPT7
- CYP17
- S17AH
- P450C17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.93 | ||
biological process | 0.9 | ||
disease | 0.79 | ||
molecular function | 0.76 | ||
cellular component | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1588.77 (req: < 5)
Gene RIFs: 311 (req: <= 3)
Antibodies: 545 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1588.77 (req: >= 5)
Gene RIFs: 311 (req: > 3)
Antibodies: 545 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 580
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (580)
Protein-Protein Interactions (127)
Nearest Tclin Targets
Pathways (24)
Reactome (10)
KEGG (6)
PathwayCommons (1)
UniProt (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Androgen biosynthesis | ||||
Reactome | Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glucocorticoid biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Androgen biosynthesis | ||||
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) | ||||
Disease | ||||
Diseases of metabolism | ||||
Glucocorticoid biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (54)
Items per page:
1 – 5 of 54
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 4 | 5 | 94.2 | |||||
6 | 4 | 3 | 1.1 | 91.7 | |||||
12 | 8 | 3 | 1.1 | 91.1 | |||||
body mass index | 5 | 4 | 6 | 84.6 | |||||
monocyte count | 2 | 2 | 2 | 84.5 | |||||
Items per page:
1 – 5 of 54
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 94.2 | |||||
3 | 1.1 | 91.7 | |||||
3 | 1.1 | 91.1 | |||||
body mass index | 6 | 84.6 | |||||
monocyte count | 2 | 84.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 17, subfamily A, polypeptide 1 | 450141 | ||||||
Macaque | cytochrome P450c17 | 678693 | ||||||
Mouse | MGI:88586 | 13074 | ||||||
Rat | RGD:2456 | 25146 | ||||||
Dog | cytochrome P450 family 17 subfamily A member 1 | VGNC:50330 | 477807 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 17, subfamily A, polypeptide 1 | |||||
Macaque | cytochrome P450c17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 17 subfamily A member 1 | |||||
Publication Statistics
PubMed Score 1588.77
PubMed score by year
PubTator Score 1029.54
PubTator score by year
Related Publications
Text Mined References (530)
GeneRif Annotations (311)
Items per page:
0 of 0
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