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Tclin
ALDH2
Aldehyde dehydrogenase, mitochondrial

Protein Summary
Description
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261733
  • ENSP00000261733
  • ENSG00000111275
  • ENST00000416293
  • ENSP00000403349

Symbol
  • ALDM
  • ALDM
  • ALDHI
  • ALDH-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological term
0.99
chemical
0.97
disease
0.97
interacting protein
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1489.61   (req: < 5)
Gene RIFs: 390   (req: <= 3)
Antibodies: 603   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1489.61   (req: >= 5)
Gene RIFs: 390   (req: > 3)
Antibodies: 603   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 82
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
disulfiram
chemical structure image
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
drinking behavior
1
1
0
6.3
96.4
3
2
0
1.9
95.5
alcohol drinking
2
1
1
2.5
95.2
alcohol consumption measurement
2
1
1
2.5
93.8
diet measurement
4
1
4
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
drinking behavior
0
6.3
96.4
0
1.9
95.5
alcohol drinking
1
2.5
95.2
alcohol consumption measurement
1
2.5
93.8
diet measurement
4
93.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 2 family member
VGNC:52040
107967644
Macaque
aldehyde dehydrogenase 2 family (mitochondrial)
713451
Mouse
MGI:99600
11669
Rat
RGD:69219
29539
Dog
aldehyde dehydrogenase 2 family (mitochondrial)
610941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 2 family member
Macaque
aldehyde dehydrogenase 2 family (mitochondrial)
Mouse
Rat
Dog
aldehyde dehydrogenase 2 family (mitochondrial)
Protein Structure (27 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05091-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Metabolism of serotonin
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Metabolism of serotonin
Neuronal System
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Sequence or structural Similarity (ISS)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (143)
1 – 10 of 143
ALDH6A1
Tbio
Family: Enzyme
Novelty: 0.03785268
p_int: 0.999999852
p_ni: 1.48e-7
p_wrong: 1e-9
Score: 0.952
Data Source: BioPlex,STRINGDB
IGHG4
Tdark
p_int: 0.999994149
p_ni: 0.00000583
p_wrong: 2.1e-8
Data Source: BioPlex
IGHG3
Tdark
p_int: 0.999824266
p_ni: 0.000175727
p_wrong: 8e-9
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.999647588
p_ni: 0.000352412
Score: 0.302
Data Source: BioPlex,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
p_int: 0.999520818
p_ni: 0.000478844
p_wrong: 3.38e-7
Score: 0.318
Data Source: BioPlex,STRINGDB
FGG
Tbio
Novelty: 0.00404457
p_int: 0.999225077
p_ni: 0.000587732
p_wrong: 0.000187191
Score: 0.269
Data Source: BioPlex,STRINGDB
FGA
Tbio
Novelty: 0.00107227
p_int: 0.998967723
p_ni: 0.001007897
p_wrong: 0.00002438
Score: 0.314
Data Source: BioPlex,STRINGDB
SERPINA1
Tbio
Novelty: 0.00014098
p_int: 0.991679777
p_ni: 0.008320109
p_wrong: 1.14e-7
Score: 0.273
Data Source: BioPlex,STRINGDB
IGKC
Tdark
p_int: 0.98698223
p_ni: 0.013017768
p_wrong: 3e-9
Data Source: BioPlex
TF
Tbio
Novelty: 0.00231826
p_int: 0.948693937
p_ni: 0.051306063
Score: 0.231
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1489.61

PubMed score by year
PubTator Score  927.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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