Tclin ALDH2 Aldehyde dehydrogenase, mitochondrial

Protein Summary

Description

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• P05091
• B4DW54
• E7EUE5
• Q03639
• Q6IB13
• Q6IV71

Gene Name

• ALDH2

Ensembl ID

• ENST00000261733
• ENSP00000261733
• ENSG00000111275
• ENST00000416293
• ENSP00000403349

Symbol

• ALDM
• ALDM
• ALDHI
• ALDH-E2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
biological term	0.99
chemical	0.97
disease	0.97
interacting protein	0.95

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Aldehyde Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Aldehyde Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1676.97   (req: < 5)

Gene RIFs: 547   (req: <= 3)

Antibodies: 603   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1676.97   (req: >= 5)

Gene RIFs: 547   (req: > 3)

Antibodies: 603   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2