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Tchem
ARG1
Arginase-1

Protein Classes
Protein Summary
Description
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356962
  • ENSP00000349446
  • ENSG00000118520
  • ENST00000368087
  • ENSP00000357066
  • ENST00000640973
  • ENSP00000492623
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological process
0.97
interacting protein
0.81
biological term
0.76
chemical
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1600.48   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 1071   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1600.48   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (96)
1 – 10 of 96
CHEMBL2326089
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CHEMBL2418830
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CHEMBL2418831
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CHEMBL2418991
Rendered image for CHEMBL2418991
CHEMBL2418829
Rendered image for CHEMBL2418829
L-nor-N-hydroxyarginine
Rendered image for L-nor-N-hydroxyarginine
CHEMBL2326090
Rendered image for CHEMBL2326090
CHEMBL2418828
Rendered image for CHEMBL2418828
CHEMBL2326087
Rendered image for CHEMBL2326087
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
6
7
6.7
94.2
vitamin D measurement
4
4
4
83.3
L-arginine measurement
1
1
0
4
71.3
4
3
3
1.1
70
creatinine measurement
2
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
6.7
94.2
vitamin D measurement
4
83.3
L-arginine measurement
0
4
71.3
3
1.1
70
creatinine measurement
2
69.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginase 1
VGNC:11033
462999
Macaque
arginase 1
710410
Mouse
MGI:88070
11846
Rat
RGD:2150
29221
Dog
arginase 1
VGNC:38041
474823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginase 1
Macaque
arginase 1
Mouse
Rat
Dog
arginase 1
Protein Structure (36 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05089-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of amino acids and derivatives
Neutrophil degranulation
Gene Ontology Terms (50)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (296)
1 – 10 of 296
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.989796093
p_ni:  0.010203907
Score:  0.202
Data Source:  BioPlex,STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.961894231
p_ni:  0.038105769
Data Source:  BioPlex
GPR18
Tchem
Family:  GPCR
Novelty:  0.0178347
p_int:  0.871080291
p_ni:  0.128919709
Score:  0.252
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.832020925
p_ni:  0.167979075
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.824128095
p_ni:  0.175871905
Data Source:  BioPlex
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.820156076
p_ni:  0.179843924
Data Source:  BioPlex
MCL1
Tchem
Novelty:  0.00046181
p_int:  0.810916811
p_ni:  0.189083189
Score:  0.225
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.79534002
p_ni:  0.204659979
Score:  0.208
Data Source:  BioPlex,STRINGDB
ARG2
Tchem
Family:  Enzyme
Novelty:  0.0006655
p_int:  0.792387839
p_ni:  0.207612161
Score:  0.876
Data Source:  BioPlex,STRINGDB
SPICE1
Tbio
Novelty:  0.19045168
p_int:  0.770778838
p_ni:  0.229221162
Score:  0.189
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1600.48

PubMed score by year
PubTator Score  369.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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