You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
APP
Amyloid-beta A4 protein

Protein Summary
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346798
  • ENSP00000284981
  • ENSG00000142192
  • ENST00000348990
  • ENSP00000345463
  • ENST00000354192
  • ENSP00000346129
  • ENST00000357903
  • ENSP00000350578
  • ENST00000358918
  • ENSP00000351796
  • ENST00000440126
  • ENSP00000387483

Symbol
  • A4
  • AD1
  • AAA
  • AD1
  • PN2
  • ABPP
  • APPI
  • CVAP
  • ABETA
  • PN-II
  • preA4
  • CTFgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11766.58   (req: < 5)
Gene RIFs: 2119   (req: <= 3)
Antibodies: 3786   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11766.58   (req: >= 5)
Gene RIFs: 2119   (req: > 3)
Antibodies: 3786   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 170
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 445
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein
VGNC:6591
473931
Mouse
MGI:88059
11820
Rat
RGD:2139
54226
Horse
amyloid beta precursor protein
VGNC:15428
100066294
Cow
amyloid beta precursor protein
VGNC:26038
280722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid beta precursor protein
Mouse
Rat
Horse
amyloid beta precursor protein
Cow
amyloid beta precursor protein
Protein Data Bank (135)
1 – 5 of 135
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (72)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Amyloid fiber formation
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Amyloid fiber formation
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Gene Ontology Terms (221)
Items per page:
10
1 – 10 of 27
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Protein-Protein Interactions (1076)
1 – 10 of 1076
CES2
Tchem
Family: Enzyme
Novelty: 0.00177726
p_int: 0.999999959
p_wrong: 4.1e-8
Score: 0.255
Data Source: BioPlex,STRINGDB
FRMD6
Tbio
Novelty: 0.0034642
p_int: 0.999993692
p_ni: 0.000006071
p_wrong: 2.37e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
APBB2
Tbio
Novelty: 0.06546724
p_int: 0.999986814
p_ni: 0.000013186
Score: 0.958
Data Source: BioPlex,STRINGDB
UTP11
Tbio
Novelty: 0.20711838
p_int: 0.999984401
p_ni: 0.000014313
p_wrong: 0.000001286
Data Source: BioPlex
SULF1
Tbio
Family: Enzyme
Novelty: 0.00992209
p_int: 0.999910216
p_ni: 0.000089672
p_wrong: 1.11e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
ZNF107
Tdark
Family: TF
Novelty: 0.07468249
p_int: 0.999763878
p_ni: 0.000236122
Score: 0.165
Data Source: BioPlex,STRINGDB
APBB3
Tbio
Novelty: 0.15864948
p_int: 0.99957742
p_ni: 0.00042258
Score: 0.681
Data Source: BioPlex,STRINGDB
INHBE
Tbio
Novelty: 0.07526145
p_int: 0.999450535
p_ni: 0.000201982
p_wrong: 0.000347482
Score: 0.274
Data Source: BioPlex,STRINGDB
APBB1
Tbio
Novelty: 0.00630564
p_int: 0.999297512
p_ni: 0.000702488
Score: 0.999
Data Source: BioPlex,STRINGDB
ZNF431
Tdark
Family: TF
Novelty: 1.38008368
p_int: 0.999136427
p_ni: 0.000008381
p_wrong: 0.000855191
Data Source: BioPlex
Publication Statistics
PubMed Score  11766.58

PubMed score by year
PubTator Score  10690.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: