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Tclin
APP
Amyloid-beta A4 protein

Protein Summary
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346798
  • ENSP00000284981
  • ENSG00000142192
  • ENST00000348990
  • ENSP00000345463
  • ENST00000354192
  • ENSP00000346129
  • ENST00000357903
  • ENSP00000350578
  • ENST00000358918
  • ENSP00000351796
  • ENST00000440126
  • ENSP00000387483

Symbol
  • A4
  • AD1
  • AAA
  • AD1
  • PN2
  • ABPP
  • APPI
  • CVAP
  • ABETA
  • PN-II
  • preA4
  • CTFgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14947.46   (req: < 5)
Gene RIFs: 2466   (req: <= 3)
Antibodies: 3786   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14947.46   (req: >= 5)
Gene RIFs: 2466   (req: > 3)
Antibodies: 3786   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 170
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 727
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4