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Tbio
ALDOB
Fructose-bisphosphate aldolase B

Protein Summary
Description
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374855
  • ENSP00000363988
  • ENSG00000136872
  • ENST00000647789
  • ENSP00000497767
  • ENST00000648064
  • ENSP00000497990
  • ENST00000648758
  • ENSP00000497731

Symbol
  • ALDB
  • ALDB
  • ALDO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
small molecule perturbation
0.87
kinase perturbation
0.71
biological process
0.67
PubMedID
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.49   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.49   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate B
VGNC:8799
464623
Macaque
aldolase, fructose-bisphosphate B
713818
Mouse
MGI:87995
230163
Rat
RGD:2090
24190
Dog
aldolase, fructose-bisphosphate B
VGNC:37792
474787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate B
Macaque
aldolase, fructose-bisphosphate B
Mouse
Rat
Dog
aldolase, fructose-bisphosphate B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Fructose catabolism
Reactome
Fructose metabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Fructose catabolism
Fructose metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Protein-Protein Interactions (126)
1 – 10 of 126
SHOC2
Tbio
Novelty: 0.01203957
p_int: 0.999635852
p_ni: 0.000057263
p_wrong: 0.000306885
Data Source: BioPlex
ALDOC
Tbio
Family: Enzyme
Novelty: 0.01552954
p_int: 0.999494531
p_ni: 0.000505469
Score: 0.806
Data Source: BioPlex,STRINGDB
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
p_int: 0.999299076
p_ni: 0.000700924
Score: 0.818
Data Source: BioPlex,STRINGDB
CHTF18
Tbio
Novelty: 0.02470494
p_int: 0.976959403
p_ni: 0.017996158
p_wrong: 0.005044438
Data Source: BioPlex
TPI1
Tbio
Family: Enzyme
Novelty: 0.00074652
Score: 0.981
Data Source: STRINGDB
PFKL
Tbio
Family: Kinase
Novelty: 0.00586306
Score: 0.976
Data Source: STRINGDB
PFKP
Tbio
Family: Kinase
Novelty: 0.00808684
Score: 0.975
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.97
Data Source: STRINGDB
PFKM
Tbio
Family: Kinase
Novelty: 0.00217816
Score: 0.97
Data Source: STRINGDB
FBP1
Tchem
Family: Enzyme
Novelty: 0.0029987
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  119.49

PubMed score by year
PubTator Score  32.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer