Tbio CHGB Secretogranin-1

Protein Summary

Description

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• P05060
• A8K021
• Q59EU9
• Q6IBS6
• Q9BQV6
• Q9UC25
• Q9UJA6

Gene Name

• CHGB

Ensembl ID

• ENST00000378961
• ENSP00000368244
• ENSG00000089199

Symbol

• SCG1
• SCG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
PubMedID	0.83
disease perturbation	0.74
histone modification site profile	0.69
transcription factor binding site profile	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.76   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.76   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0