Protein Summary
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
- ENST00000378961
- ENSP00000368244
- ENSG00000089199
- SCG1
- SCG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
PubMedID | 0.83 | ||
disease perturbation | 0.74 | ||
histone modification site profile | 0.69 | ||
transcription factor binding site profile | 0.64 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.73 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 183.73 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chromogranin B | VGNC:6079 | 470034 | |||||
Macaque | chromogranin B | 719171 | ||||||
Mouse | MGI:88395 | 12653 | ||||||
Rat | RGD:2339 | 24259 | ||||||
Dog | chromogranin B | VGNC:39212 | 477165 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chromogranin B | |||||
Macaque | chromogranin B | |||||
Mouse | ||||||
Rat | ||||||
Dog | chromogranin B | |||||
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (174)
1 – 10 of 174
SCG2
Novelty: 0.00389492
Score: 0.992
Data Source: STRINGDB
SCG3
Novelty: 0.02153066
Score: 0.979
Data Source: STRINGDB
VGF
Novelty: 0.00521876
Score: 0.968
Data Source: STRINGDB
PENK
Novelty: 0.00074167
Score: 0.958
Data Source: STRINGDB
CHGA
Novelty: 0.00033267
Score: 0.943
Data Source: STRINGDB
TGOLN2
Novelty: 0.005107
Score: 0.93
Data Source: STRINGDB
CST3
Novelty: 0.00021856
Score: 0.928
Data Source: STRINGDB
MFGE8
Novelty: 0.00132919
Score: 0.922
Data Source: STRINGDB
FAM20C
Family: Enzyme
Novelty: 0.00318966
Score: 0.92
Data Source: STRINGDB
FN1
Novelty: 0.00003647
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score 183.73
PubMed score by year
PubTator Score 195.73
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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