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Tclin
ATP1A1
Sodium/potassium-transporting ATPase subunit alpha-1

Protein Summary
Description
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295598
  • ENSP00000295598
  • ENSG00000163399
  • ENST00000369496
  • ENSP00000358508
  • ENST00000537345
  • ENSP00000445306

Symbol
  • CMT2DD
  • HOMGSMR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
molecular function
1
protein domain
0.99
biological process
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.59   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.59   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
81.9
diastolic blood pressure
1
1
1
29
leukocyte count
1
1
1
26.6
hip circumference
1
1
1
24.5
response to sulfasalazine
1
1
0
9.5
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
81.9
diastolic blood pressure
1
29
leukocyte count
1
26.6
hip circumference
1
24.5
response to sulfasalazine
0
9.5
14.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit alpha 1
VGNC:8029
457152
Macaque
ATPase Na+/K+ transporting subunit alpha 1
710368
Mouse
MGI:88105
11928
Rat
RGD:2167
24211
Dog
ATPase Na+/K+ transporting subunit alpha 1
VGNC:38245
403992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit alpha 1
Macaque
ATPase Na+/K+ transporting subunit alpha 1
Mouse
Rat
Dog
ATPase Na+/K+ transporting subunit alpha 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P05023-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (128)
1 – 10 of 128
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.997
Data Source:  Reactome,STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.995
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.985
Data Source:  Reactome,STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.983
Data Source:  Reactome,STRINGDB
FXYD7
Tbio
Family:  IC
Novelty:  0.08820333
Score:  0.942
Data Source:  STRINGDB
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
Score:  0.942
Data Source:  STRINGDB
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
Score:  0.917
Data Source:  STRINGDB
FXYD3
Tbio
Family:  IC
Novelty:  0.01217832
Score:  0.915
Data Source:  STRINGDB
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
Score:  0.912
Data Source:  STRINGDB
FXYD4
Tdark
Family:  IC
Novelty:  0.11545177
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  87.59

PubMed score by year
PubTator Score  62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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