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Tbio
IGF1
Insulin-like growth factor I

Protein Summary
Description
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307046
  • ENSP00000302665
  • ENSG00000017427
  • ENST00000337514
  • ENSP00000337612
  • ENST00000392904
  • ENSP00000376637
  • ENST00000392905
  • ENSP00000376638
  • ENST00000424202
  • ENSP00000416811
  • ENST00000644491
  • ENSP00000494228

Symbol
  • IBP1
  • IGF
  • MGF
  • IGFI
  • IGF-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
0.93
disease
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30609.05   (req: < 5)
Gene RIFs: 1510   (req: <= 3)
Antibodies: 1322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30609.05   (req: >= 5)
Gene RIFs: 1510   (req: > 3)
Antibodies: 1322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 71
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0