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Tbio
IFNA4
Interferon alpha-4

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421715
  • ENSP00000412897
  • ENSG00000236637

Symbol
  • INFA4
  • IFN-alpha4a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
disease perturbation
0.62
kinase perturbation
0.54
pathway
0.54
transcription factor
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (55)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (84)
1 – 10 of 84
IFNA21
Tbio
Novelty: 0.00581034
p_int: 1
Score: 0.964
Data Source: BioPlex,STRINGDB
IFNA7
Tdark
Novelty: 0.14618009
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
IFNA5
Tbio
Novelty: 0.02838784
p_int: 0.99999941
p_ni: 5.9e-7
Score: 0.833
Data Source: BioPlex,STRINGDB
IFNA8
Tbio
Novelty: 0.0310922
p_int: 0.999997594
p_wrong: 0.000002406
Score: 0.982
Data Source: BioPlex,STRINGDB
IFNA1
Tbio
Novelty: 0.0000962
p_int: 0.999995794
p_ni: 0.000004206
Data Source: BioPlex
TNNI3
Tbio
Novelty: 0.00020053
p_int: 0.999969748
p_ni: 0.000030252
Score: 0.622
Data Source: BioPlex,STRINGDB
IFNA2
Tbio
Novelty: 0.00032935
p_int: 0.999893357
p_ni: 2e-9
p_wrong: 0.000106642
Score: 0.982
Data Source: BioPlex,STRINGDB
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.999829099
p_ni: 0.000170849
p_wrong: 5.2e-8
Score: 0.926
Data Source: BioPlex,STRINGDB
RECK
Tbio
Novelty: 0.00409224
p_int: 0.980765389
p_ni: 0.01923461
p_wrong: 1e-9
Score: 0.325
Data Source: BioPlex,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.75

PubMed score by year
PubTator Score  26.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer