Tbio IFNA4 Interferon alpha-4

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P05014
• P13358
• Q14CS4
• Q5VV15
• IFN-alpha-4

Gene Name

• IFNA4

Ensembl ID

• ENST00000421715
• ENSP00000412897
• ENSG00000236637

Symbol

• INFA4
• IFN-alpha4a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
disease perturbation	0.62
kinase perturbation	0.54
pathway	0.54
transcription factor	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.82   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.82   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

IFNA21

Tbio

Novelty:  0.00581034

p_int:  1

Score:  0.964

Data Source:  BioPlex,STRINGDB

IFNA7

Tdark

Novelty:  0.14618009

p_int:  0.999999998

p_wrong:  2e-9

Score:  0.966

Data Source:  BioPlex,STRINGDB

IFNA5

Tbio

Novelty:  0.02838784

p_int:  0.99999941

p_ni:  5.9e-7

Score:  0.833

Data Source:  BioPlex,STRINGDB

IFNA8

Tbio

Novelty:  0.0310922

p_int:  0.999997594

p_wrong:  0.000002406

Score:  0.982

Data Source:  BioPlex,STRINGDB

IFNA1

Tbio

Novelty:  0.0000962

p_int:  0.999995794

p_ni:  0.000004206

Data Source:  BioPlex

TNNI3

Tbio

Novelty:  0.00020053

p_int:  0.999969748

p_ni:  0.000030252

Score:  0.622

Data Source:  BioPlex,STRINGDB

IFNA2

Tbio

Novelty:  0.00032935

p_int:  0.999893357

p_ni:  2e-9

p_wrong:  0.000106642

Score:  0.982

Data Source:  BioPlex,STRINGDB

ISG15

Tbio

Novelty:  0.00203781

p_int:  0.999829099

p_ni:  0.000170849

p_wrong:  5.2e-8

Score:  0.926

Data Source:  BioPlex,STRINGDB

RECK

Tbio

Novelty:  0.00409224

p_int:  0.980765389

p_ni:  0.01923461

p_wrong:  1e-9

Score:  0.325

Data Source:  BioPlex,STRINGDB

IRF3

Tbio

Family:  TF

Novelty:  0.00099474

Score:  0.968

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (17)

1 – 1 of 1

TLR9

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Toll-like receptor signaling pathway

2: Tuberculosis

3: Measles

4: Herpes simplex virus 1 infection

Pathways (55)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (11)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (2)

Components (2)

Processes (13)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Polymorphism
Reference proteome
Secreted
Signal

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype
immune system phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 16.82

PubMed score by year

Reset Zoom

PubTator Score 26.50

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (18)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title