Protein Summary
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
- ENST00000421715
- ENSP00000412897
- ENSG00000236637
- INFA4
- IFN-alpha4a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.82 | ||
disease perturbation | 0.62 | ||
kinase perturbation | 0.54 | ||
pathway | 0.54 | ||
transcription factor | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.82 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.82 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (84)
IFNA7
Novelty: 0.14618009
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
IFNA5
Novelty: 0.02838784
p_int: 0.99999941
p_ni: 5.9e-7
Score: 0.833
Data Source: BioPlex,STRINGDB
IFNA8
Novelty: 0.0310922
p_int: 0.999997594
p_wrong: 0.000002406
Score: 0.982
Data Source: BioPlex,STRINGDB
TNNI3
Novelty: 0.00020053
p_int: 0.999969748
p_ni: 0.000030252
Score: 0.622
Data Source: BioPlex,STRINGDB
IFNA2
Novelty: 0.00032935
p_int: 0.999893357
p_ni: 2e-9
p_wrong: 0.000106642
Score: 0.982
Data Source: BioPlex,STRINGDB
ISG15
Novelty: 0.00203781
p_int: 0.999829099
p_ni: 0.000170849
p_wrong: 5.2e-8
Score: 0.926
Data Source: BioPlex,STRINGDB
RECK
Novelty: 0.00409224
p_int: 0.980765389
p_ni: 0.01923461
p_wrong: 1e-9
Score: 0.325
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (1)
Downstream (17)
1 – 1 of 1
Pathways (55)
Reactome (10)
KEGG (22)
PathwayCommons (12)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (2)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 16.82
PubMed score by year
PubTator Score 26.50
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (5)
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PMID | Year | Title |
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