Tbio IFNA6 Interferon alpha-6

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P05013
• Q5VYQ1
• IFN-alpha-6

Gene Name

• IFNA6

Ensembl ID

• ENST00000380210
• ENSP00000369558
• ENSG00000120235

Symbol

• IFN-alphaK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
cell type or tissue	0.67
tissue	0.53
pathway	0.52
phenotype	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (82)

Explore Interacting Targets

1 – 10 of 82

• See Interactions on String-DB

IFNA5

Tbio

Novelty:  0.02838784

p_int:  0.999999792

p_ni:  1.99e-7

p_wrong:  1e-8

Score:  0.852

Data Source:  BioPlex,STRINGDB

IFNA1

Tbio

Novelty:  0.0000962

p_int:  0.999999739

p_ni:  1.3e-8

p_wrong:  2.48e-7

Score:  0.836

Data Source:  BioPlex,STRINGDB

IFNA21

Tbio

Novelty:  0.00581034

p_int:  0.999999456

p_wrong:  5.43e-7

Score:  0.982

Data Source:  BioPlex,STRINGDB

IFNA14

Tbio

Novelty:  0.17853653

p_int:  0.998467302

p_ni:  0.000203693

p_wrong:  0.001329004

Score:  0.99

Data Source:  BioPlex,STRINGDB

IFNAR1

Tclin

Novelty:  0.00175488

Score:  0.936

Data Source:  STRINGDB

IRF7

Tbio

Family:  TF

Novelty:  0.0021839

Score:  0.932

Data Source:  STRINGDB

IRF3

Tbio

Family:  TF

Novelty:  0.00099474

Score:  0.927

Data Source:  STRINGDB

IFNAR2

Tclin

Novelty:  0.00453303

Score:  0.926

Data Source:  STRINGDB

IRF1

Tbio

Family:  TF

Novelty:  0.00099983

Score:  0.923

Data Source:  STRINGDB

IRF9

Tbio

Family:  TF

Novelty:  0.00751233

Score:  0.918

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (17)

1 – 1 of 1

TLR9

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Toll-like receptor signaling pathway

2: Tuberculosis

3: Measles

4: Herpes simplex virus 1 infection

Pathways (441)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (397)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (2)

Processes (12)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
epilepsy	EFO_0000474	1	1	0	10.7	11.2
maculopapular eruption	EFO_1001253	1	1	0	10.7	11.2
response to lamotrigine	EFO_0007661	1	1	0	10.7	11.2
neutrophil count	EFO_0004833	3	1	3		8.5
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
epilepsy	EFO_0000474	0	10.7	11.2
maculopapular eruption	EFO_1001253	0	10.7	11.2
response to lamotrigine	EFO_0007661	0	10.7	11.2
neutrophil count	EFO_0004833	3		8.5
lymphocyte percentage of leukocytes	EFO_0007993	1		8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
epilepsy
lymphocyte percentage of leukocytes
maculopapular eruption
neutrophil count
neutrophil percentage of leukocytes
response to lamotrigine

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	interferon alpha 16	MGI:3649260	230398
Rat	interferon, alpha 1	RGD:1306135	690894
Horse	interferon alpha-1		100629951
Cow	interferon alpha-B-like		618947

Species	Name	OMA	EggNOG	Inparanoid
Mouse	interferon alpha 16
Rat	interferon, alpha 1
Horse	interferon alpha-1
Cow	interferon alpha-B-like

Publication Statistics

PubMed Score 17.42

PubMed score by year

Reset Zoom

PubTator Score 14.91

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (18)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title