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Tbio
IFNA6
Interferon alpha-6

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380210
  • ENSP00000369558
  • ENSG00000120235

Symbol
  • IFN-alphaK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.67
tissue
0.53
pathway
0.52
phenotype
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999999792
p_ni:  1.99e-7
p_wrong:  1e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.999999739
p_ni:  1.3e-8
p_wrong:  2.48e-7
Score:  0.836
Data Source:  BioPlex,STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.999999456
p_wrong:  5.43e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
IFNA14
Tbio
Novelty:  0.17853653
p_int:  0.998467302
p_ni:  0.000203693
p_wrong:  0.001329004
Score:  0.99
Data Source:  BioPlex,STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.936
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.932
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.927
Data Source:  STRINGDB
IFNAR2
Tclin
Novelty:  0.00453303
Score:  0.926
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.923
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.918
Data Source:  STRINGDB
Pathways (441)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
10.7
11.2
maculopapular eruption
1
1
0
10.7
11.2
response to lamotrigine
1
1
0
10.7
11.2
neutrophil count
3
1
3
8.5
lymphocyte percentage of leukocytes
1
1
1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
10.7
11.2
maculopapular eruption
0
10.7
11.2
response to lamotrigine
0
10.7
11.2
neutrophil count
3
8.5
lymphocyte percentage of leukocytes
1
8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3649260
230398
Rat
RGD:1306135
690894
Horse
interferon alpha-1
100629951
Cow
interferon alpha-B-like
618947
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
interferon alpha-1
Cow
interferon alpha-B-like
Publication Statistics
PubMed Score 17.42
PubMed score by year
PubTator Score 14.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title