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Tbio
IFNA6
Interferon alpha-6

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380210
  • ENSP00000369558
  • ENSG00000120235

Symbol
  • IFN-alphaK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.67
tissue
0.53
pathway
0.52
phenotype
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)
View Publications
Gene RIFs: 4   (req: <= 3)
View Gene RIFs
Antibodies: 165   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (441)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
77 targets
R-HSA-168928
Reactome
Factors involved in megakaryocyte development and platelet production
139 targets
R-HSA-983231
Reactome
Hemostasis
666 targets
R-HSA-109582
Reactome
Immune System
2246 targets
R-HSA-168256
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta
77 targets
R-HSA-168928
Factors involved in megakaryocyte development and platelet production
139 targets
R-HSA-983231
Hemostasis
666 targets
R-HSA-109582
Immune System
2246 targets
R-HSA-168256
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
cytokine activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
type I interferon receptor binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (82)
1 – 10 of 82
IFNA5
Tbio
Novelty: 0.01718471
p_int: 0.999999792
p_ni: 1.99e-7
p_wrong: 1e-8
Score: 0.852
Data Source: BioPlex,STRINGDB
IFNA1
Tbio
Novelty: 0.00013873
p_int: 0.999999739
p_ni: 1.3e-8
p_wrong: 2.48e-7
Score: 0.836
Data Source: BioPlex,STRINGDB
IFNA21
Tbio
Novelty: 0.00852658
p_int: 0.999999456
p_wrong: 5.43e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
IFNA14
Tbio
Novelty: 0.42599235
p_int: 0.998467302
p_ni: 0.000203693
p_wrong: 0.001329004
Score: 0.99
Data Source: BioPlex,STRINGDB
IFNAR1
Tclin
Novelty: 0.00224149
Score: 0.936
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.932
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00132895
Score: 0.927
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00573978
Score: 0.926
Data Source: STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00077466
Score: 0.923
Data Source: STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.01154411
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.66

PubMed score by year
PubTator Score  14.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer