SLC4A2
Anion exchange protein 2
Protein Summary
Plasma membrane anion exchange protein of wide distribution. This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]
- ENST00000392826
- ENSP00000376571
- ENSG00000164889
- ENST00000413384
- ENSP00000405600
- ENST00000461735
- ENSP00000419164
- ENST00000485713
- ENSP00000419412
- AE2
- EPB3L1
- HKB3
- MPB3L
- AE2
- HKB3
- BND3L
- NBND3
- EPB3L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
disease perturbation | 0.9 | ||
transcription factor | 0.86 | ||
transcription factor binding site profile | 0.73 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.23 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.23 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0