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Tchem
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266027
  • ENSP00000266027
  • ENSG00000114353
  • ENST00000313601
  • ENSP00000312999
  • ENST00000422163
  • ENSP00000406871
  • ENST00000440628
  • ENSP00000395736
  • ENST00000451956
  • ENSP00000406369

Symbol
  • GNAI2B
  • GIP
  • GNAI2B
  • H_LUCA15.1
  • H_LUCA16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.99
disease perturbation
0.95
pathway
0.94
transcription factor perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
alisertib
Rendered image for alisertib
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
8
16
99.6
reticulocyte count
2
5
10
99.2
self reported educational attainment
4
4
3
7.2
97.4
intelligence
4
11
7
6.7
92.8
mathematical ability
3
2
4
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
16
99.6
reticulocyte count
10
99.2
self reported educational attainment
3
7.2
97.4
intelligence
7
6.7
92.8
mathematical ability
4
92.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i2
VGNC:10040
744773
Macaque
G protein subunit alpha i2
703780
Mouse
MGI:95772
14678
Rat
RGD:620243
81664
Dog
G protein subunit alpha i2
VGNC:41302
442957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i2
Macaque
G protein subunit alpha i2
Mouse
Rat
Dog
G protein subunit alpha i2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04899-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (120)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Chaperonin-mediated protein folding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Activation of GABAB receptors
Adenylate cyclase inhibitory pathway
Adrenaline,noradrenaline inhibits insulin secretion
Chaperonin-mediated protein folding
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (460)
1 – 10 of 460
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.999999531
p_ni:  4.63e-7
p_wrong:  6e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.999997809
p_ni:  0.000002191
Score:  0.979
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.999962328
p_ni:  0.000037672
Score:  0.977
Data Source:  BioPlex,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999581759
p_ni:  0.000418241
Score:  0.98
Data Source:  BioPlex,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
p_int:  0.999139884
p_ni:  0.000651863
p_wrong:  0.000208252
Score:  0.969
Data Source:  BioPlex,STRINGDB
GNG7
Tbio
Novelty:  0.08478455
p_int:  0.994880434
p_ni:  0.005119432
p_wrong:  1.34e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.994298471
p_ni:  0.005701222
p_wrong:  3.07e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
GNG10
Tdark
Novelty:  0.37659459
p_int:  0.982240675
p_ni:  0.015610855
p_wrong:  0.00214847
Score:  0.982
Data Source:  BioPlex,STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
p_int:  0.978902856
p_ni:  0.01356293
p_wrong:  0.007534214
Score:  0.173
Data Source:  BioPlex,STRINGDB
ADIPOR1
Tbio
Novelty:  0.00273623
p_int:  0.969379759
p_ni:  0.030300607
p_wrong:  0.000319634
Score:  0.241
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.29

PubMed score by year
PubTator Score  13.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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