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Tbio
RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Protein Summary
Description
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate bin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296255
  • ENSP00000296255
  • ENSG00000163902

Symbol
  • OST1
  • RBPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
transcription factor perturbation
0.91
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 493   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (289)
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.986173861
p_ni:  0.013826139
Score:  0.416
Data Source:  BioPlex,STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.96755565
p_ni:  0.03244435
Score:  0.999
Data Source:  BioPlex,STRINGDB
STT3B
Tbio
Family:  Enzyme
Novelty:  0.05813174
Score:  0.999
Data Source:  STRINGDB
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.999
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.999
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.999
Data Source:  STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
Score:  0.998
Data Source:  STRINGDB
RPL27
Tbio
Novelty:  0.0157566
Score:  0.996
Data Source:  STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
Score:  0.996
Data Source:  STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational protein modification
SRP-dependent cotranslational protein targeting to membrane
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
8
10
13
9.4
99.7
eosinophil percentage of leukocytes
2
7
7
99.3
monocyte count
6
6
8
99.3
monocyte percentage of leukocytes
2
7
8
99.1
basophil count
7
5
9
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
13
9.4
99.7
eosinophil percentage of leukocytes
7
99.3
monocyte count
8
99.3
monocyte percentage of leukocytes
8
99.1
basophil count
9
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribophorin I
VGNC:2544
460673
Macaque
ribophorin I
705437
Mouse
MGI:98084
103963
Rat
RGD:3594
25596
Dog
ribophorin I
VGNC:45721
476516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribophorin I
Macaque
ribophorin I
Mouse
Rat
Dog
ribophorin I
Publication Statistics
PubMed Score 108.42
PubMed score by year
PubTator Score 74.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title