Tbio RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

Protein Summary

Description

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04843
• B2R5Z0
• D3DNB6
• Q68DT1

Gene Name

• RPN1

Ensembl ID

• ENST00000296255
• ENSP00000296255
• ENSG00000163902

Symbol

• OST1
• RBPH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
transcription factor perturbation	0.91
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.92   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 493   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.92   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0