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Tchem
CYBB
Cytochrome b-245 heavy chain

Protein Summary
Description
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent fail ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378588
  • ENSP00000367851
  • ENSG00000165168

Symbol
  • NOX2
  • CGD
  • NOX2
  • IMD34
  • AMCBX2
  • GP91-1
  • GP91PHOX
  • p91-PHOX
  • GP91-PHOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
PubMedID
0.99
molecular function
0.98
chemical
0.86
protein domain
0.85


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2116.24   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2116.24   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-245 beta chain
VGNC:10401
465566
Macaque
cytochrome b-245 heavy chain
696542
Mouse
MGI:88574
13058
Rat
RGD:620574
66021
Horse
cytochrome b-245 beta chain
VGNC:50467
100050132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-245 beta chain
Macaque
cytochrome b-245 heavy chain
Mouse
Rat
Horse
cytochrome b-245 beta chain
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04839-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cellular responses to external stimuli
Cellular responses to stress
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (39)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (337)
1 – 10 of 337
NCF1
Tbio
Novelty:  0.00120288
Score:  0.998
Data Source:  Reactome,STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.998
Data Source:  Reactome,STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.997
Data Source:  Reactome,STRINGDB
NCF4
Tbio
Novelty:  0.00560244
Score:  0.996
Data Source:  Reactome,STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.987
Data Source:  Reactome,STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.977
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.968
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.965
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.958
Data Source:  Reactome,STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2116.24

PubMed score by year
PubTator Score  799.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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