Tchem CYBB Cytochrome b-245 heavy chain

Protein Summary

Description

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04839
• A8K138
• Q2PP16

Gene Name

• CYBB

Ensembl ID

• ENST00000378588
• ENSP00000367851
• ENSG00000165168

Symbol

• NOX2
• CGD
• NOX2
• IMD34
• AMCBX2
• GP91-1
• GP91PHOX
• p91-PHOX
• GP91-PHOX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
PubMedID	0.99
molecular function	0.98
chemical	0.86
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome B-245 Heavy Chain

DTO Classes

Protein / Ion Channel / Phagocyte (Gp91(phox)) Nadph Oxidase Family / Cytochrome B-245 Heavy Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2367.82   (req: < 5)

Gene RIFs: 295   (req: <= 3)

Antibodies: 446   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2367.82   (req: >= 5)

Gene RIFs: 295   (req: > 3)

Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0