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Tclin
TYMS
Thymidylate synthase

Protein Summary
Description
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323224
  • ENSP00000314727
  • ENSG00000176890
  • ENST00000323250
  • ENSP00000314902
  • ENST00000323274
  • ENSP00000315644

Symbol
  • TS
  • TS
  • TMS
  • HST422
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
co-expressed gene
0.97
molecular function
0.95
disease
0.94
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 932.29   (req: < 5)
Gene RIFs: 369   (req: <= 3)
Antibodies: 1067   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 932.29   (req: >= 5)
Gene RIFs: 369   (req: > 3)
Antibodies: 1067   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 279
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
54.8
telomere length
1
1
1
37
mean corpuscular volume
1
1
1
31.3
mean reticulocyte volume
1
1
1
27.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
54.8
telomere length
1
37
mean corpuscular volume
1
31.3
mean reticulocyte volume
1
27.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymidylate synthetase
VGNC:5220
740018
Macaque
thymidylate synthetase
697580
Mouse
MGI:98878
22171
Rat
RGD:3921
29261
Dog
thymidylate synthetase
VGNC:48025
607417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymidylate synthetase
Macaque
thymidylate synthetase
Mouse
Rat
Dog
thymidylate synthetase
Protein Structure (50 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04818-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 50
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Reactome
Interconversion of nucleotide di- and triphosphates
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Interconversion of nucleotide di- and triphosphates
Gene Ontology Terms (37)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (397)
1 – 10 of 397
LATS1
Tbio
Family: Kinase
Novelty: 0.00369058
p_int: 0.976934142
p_ni: 0.023065858
Score: 0.222
Data Source: BioPlex,STRINGDB
PKIG
Tbio
Family: Enzyme
Novelty: 0.13489486
p_int: 0.954347531
p_ni: 0.045652469
Score: 0.416
Data Source: BioPlex,STRINGDB
LIMS1
Tbio
Novelty: 0.00648304
p_int: 0.948573579
p_ni: 0.051426421
Score: 0.252
Data Source: BioPlex,STRINGDB
RTN1
Tbio
Novelty: 0.01828064
p_int: 0.920930852
p_ni: 0.079069148
Score: 0.19
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.894960544
p_ni: 0.105039455
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
ARHGEF35
Tdark
Novelty: 4.94268866
p_int: 0.865793269
p_ni: 0.13420673
Score: 0.313
Data Source: BioPlex,STRINGDB
DHFR
Tclin
Family: Enzyme
Novelty: 0.00074557
Score: 0.999
Data Source: STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.0026993
Score: 0.999
Data Source: STRINGDB
TK1
Tchem
Family: Kinase
Novelty: 0.00139343
Score: 0.997
Data Source: STRINGDB
DCTD
Tbio
Family: Enzyme
Novelty: 0.02275597
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  932.29

PubMed score by year
PubTator Score  2447.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer