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Tbio
RLN1
Prorelaxin H1

Protein Summary
Description
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223862
  • ENSP00000223862
  • ENSG00000107018

Symbol
  • H1
  • H1RLX
  • RLXH1
  • bA12D24.3.1
  • bA12D24.3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.6
gene perturbation
0.59
protein domain
0.58
phenotype
0.57
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.58   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.58   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (11)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (102)
1 – 10 of 102
RLN2
Tbio
Novelty: 0.00846462
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.845
Data Source: BioPlex,STRINGDB
GLB1L
Tdark
Family: Enzyme
Novelty: 1.81959565
p_int: 0.99993175
p_ni: 0.000068229
p_wrong: 2.1e-8
Data Source: BioPlex
LARGE1
Tbio
Family: Enzyme
Novelty: 0.00901516
p_int: 0.999860821
p_ni: 0.000137902
p_wrong: 0.000001278
Data Source: BioPlex
VWDE
Tdark
Novelty: 0.7751938
p_int: 0.999809743
p_ni: 0.000189468
p_wrong: 7.89e-7
Data Source: BioPlex
CTSF
Tchem
Family: Enzyme
Novelty: 0.02020345
p_int: 0.999726746
p_ni: 0.000265819
p_wrong: 0.000007435
Data Source: BioPlex
SEMA6A
Tbio
Novelty: 0.0073015
p_int: 0.999512341
p_ni: 0.000487651
p_wrong: 8e-9
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00198736
p_int: 0.99941834
p_ni: 0.000179682
p_wrong: 0.000401978
Data Source: BioPlex
PDGFC
Tbio
Novelty: 0.00874564
p_int: 0.999322546
p_ni: 0.000483512
p_wrong: 0.000193942
Data Source: BioPlex
LMLN
Tdark
Family: Enzyme
Novelty: 0.00382438
p_int: 0.999277394
p_ni: 0.000619623
p_wrong: 0.000102983
Data Source: BioPlex
EOGT
Tbio
Family: Enzyme
Novelty: 0.17308881
p_int: 0.999011534
p_ni: 0.000988464
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  15.58

PubMed score by year
PubTator Score  34.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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