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Tchem
CYP1A1
Cytochrome P450 1A1

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379727
  • ENSP00000369050
  • ENSG00000140465
  • ENST00000395048
  • ENSP00000378488
  • ENST00000562201
  • ENSP00000455340
  • ENST00000564596
  • ENSP00000457668
  • ENST00000567032
  • ENSP00000456585
  • ENST00000569630
  • ENSP00000455051

Symbol
  • AHH
  • AHRR
  • CP11
  • CYP1
  • CYPIA1
  • P1-450
  • P450-C
  • P450DX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
gene perturbation
0.97
biological process
0.96
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3498.63   (req: < 5)
Gene RIFs: 606   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3498.63   (req: >= 5)
Gene RIFs: 606   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of protectins
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of protectins
Biosynthesis of specialized proresolving mediators (SPMs)
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (234)
1 – 10 of 234
HPCAL4
Tdark
Novelty: 0.25743181
p_int: 0.999996622
p_ni: 0.000003354
p_wrong: 2.4e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
RECQL
Tbio
Family: Enzyme
Novelty: 0.01000472
p_int: 0.999987991
p_ni: 0.000011999
p_wrong: 1e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
HPCAL1
Tbio
Novelty: 0.05365241
p_int: 0.999980539
p_ni: 0.000019349
p_wrong: 1.11e-7
Data Source: BioPlex
SBDS
Tbio
Novelty: 0.00526647
p_int: 0.999728213
p_ni: 0.000124322
p_wrong: 0.000147464
Score: 0.179
Data Source: BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty: 0.00789441
p_int: 0.998519212
p_ni: 0.001394258
p_wrong: 0.00008653
Data Source: BioPlex
EMG1
Tbio
Family: Enzyme
Novelty: 0.00805629
p_int: 0.998182292
p_ni: 0.000001915
p_wrong: 0.001815794
Score: 0.225
Data Source: BioPlex,STRINGDB
AFDN
Tbio
Novelty: 0.00626505
p_int: 0.998142363
p_ni: 0.001850871
p_wrong: 0.000006766
Score: 0.158
Data Source: BioPlex,STRINGDB
EIF2A
Tbio
Novelty: 0.16696482
p_int: 0.996857114
p_ni: 0.001757229
p_wrong: 0.001385656
Data Source: BioPlex
LETM1
Tbio
Novelty: 0.02313543
p_int: 0.996508533
p_ni: 0.003491447
p_wrong: 2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
HDLBP
Tbio
Novelty: 0.0098661
p_int: 0.995602374
p_ni: 0.004397626
Score: 0.221
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3498.63

PubMed score by year
PubTator Score  2134.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY
1-70
GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQN
70-140
GLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN
140-210
HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD
210-280
ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV
280-350
IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
350-420
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM
420-490
TPIYGLTMKHACCEHFQMQLRS
490-512
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS