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Tchem
CYP1A1
Cytochrome P450 1A1

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379727
  • ENSP00000369050
  • ENSG00000140465
  • ENST00000395048
  • ENSP00000378488
  • ENST00000562201
  • ENSP00000455340
  • ENST00000564596
  • ENSP00000457668
  • ENST00000567032
  • ENSP00000456585
  • ENST00000569630
  • ENSP00000455051

Symbol
  • AHH
  • AHRR
  • CP11
  • CYP1
  • CYPIA1
  • P1-450
  • P450-C
  • P450DX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
gene perturbation
0.97
biological process
0.96
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4403.79   (req: < 5)
Gene RIFs: 606   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4403.79   (req: >= 5)
Gene RIFs: 606   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption
5
2
5
95.3
urinary albumin to creatinine ratio
4
2
4
84.9
caffeine metabolite measurement
2
2
0
9
83.3
albuminuria
2
2
2
80.6
cups of coffee per day measurement
2
1
2
44.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption
5
95.3
urinary albumin to creatinine ratio
4
84.9
caffeine metabolite measurement
0
9
83.3
albuminuria
2
80.6
cups of coffee per day measurement
2
44.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 1 subfamily A member 1
VGNC:6448
453744
Macaque
cytochrome P450, family 1, subfamily A, polypeptide 1
678694
Mouse
MGI:88588
13076
Rat
RGD:2458
24296
Dog
cytochrome P450 family 1 subfamily A member 1
VGNC:50332
100686778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 1 subfamily A member 1
Macaque
cytochrome P450, family 1, subfamily A, polypeptide 1
Mouse
Rat
Dog
cytochrome P450 family 1 subfamily A member 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04798-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of protectins
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of protectins
Biosynthesis of specialized proresolving mediators (SPMs)
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (234)
1 – 10 of 234
HPCAL4
Tdark
Novelty: 0.26673582
p_int: 0.999996622
p_ni: 0.000003354
p_wrong: 2.4e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
RECQL
Tbio
Family: Enzyme
Novelty: 0.00840137
p_int: 0.999987991
p_ni: 0.000011999
p_wrong: 1e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
HPCAL1
Tbio
Novelty: 0.04434155
p_int: 0.999980539
p_ni: 0.000019349
p_wrong: 1.11e-7
Data Source: BioPlex
SBDS
Tbio
Novelty: 0.00818779
p_int: 0.999728213
p_ni: 0.000124322
p_wrong: 0.000147464
Score: 0.179
Data Source: BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty: 0.0189038
p_int: 0.998519212
p_ni: 0.001394258
p_wrong: 0.00008653
Data Source: BioPlex
EMG1
Tbio
Family: Enzyme
Novelty: 0.00462566
p_int: 0.998182292
p_ni: 0.000001915
p_wrong: 0.001815794
Score: 0.225
Data Source: BioPlex,STRINGDB
AFDN
Tbio
Novelty: 0.00372947
p_int: 0.998142363
p_ni: 0.001850871
p_wrong: 0.000006766
Score: 0.158
Data Source: BioPlex,STRINGDB
EIF2A
Tbio
Novelty: 0.08652858
p_int: 0.996857114
p_ni: 0.001757229
p_wrong: 0.001385656
Data Source: BioPlex
LETM1
Tbio
Novelty: 0.01542461
p_int: 0.996508533
p_ni: 0.003491447
p_wrong: 2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
HDLBP
Tbio
Novelty: 0.00979636
p_int: 0.995602374
p_ni: 0.004397626
Score: 0.221
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4403.79

PubMed score by year
PubTator Score  2134.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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