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Tchem
HSPB1
Heat shock protein beta-1

Protein Summary
Description
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248553
  • ENSP00000248553
  • ENSG00000106211

Symbol
  • HSP27
  • HSP28
  • CMT2F
  • HMN2B
  • HSP27
  • HSP28
  • Hsp25
  • SRP27
  • HS.76067
  • HEL-S-102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
interacting protein
1
hub protein
0.99
kinase
0.99
PubMedID
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1260.08   (req: < 5)
Gene RIFs: 377   (req: <= 3)
Antibodies: 2874   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1260.08   (req: >= 5)
Gene RIFs: 377   (req: > 3)
Antibodies: 2874   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 1
VGNC:7394
463488
Macaque
heat shock protein family B (small) member 1
715615
Mouse
MGI:96240
15507
Rat
RGD:61306
24471
Dog
heat shock protein family B (small) member 1
VGNC:53534
403979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family B (small) member 1
Macaque
heat shock protein family B (small) member 1
Mouse
Rat
Dog
heat shock protein family B (small) member 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04792-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Metabolism of RNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Metabolism of RNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Gene Ontology Terms (42)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (275)
1 – 10 of 275
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.98547877
p_ni: 0.01452123
Score: 0.525
Data Source: BioPlex,STRINGDB
HSPB6
Tbio
Novelty: 0.00317712
p_int: 0.982747402
p_ni: 0.017252598
Score: 0.611
Data Source: BioPlex,STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.979093485
p_ni: 0.020906505
p_wrong: 1e-8
Score: 0.513
Data Source: BioPlex,STRINGDB
HSPB2
Tbio
Novelty: 0.00103909
p_int: 0.918450689
p_ni: 0.081549311
Score: 0.196
Data Source: BioPlex,STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00486452
Score: 0.993
Data Source: STRINGDB
DAXX
Tbio
Novelty: 0.00348585
Score: 0.991
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.99
Data Source: STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
Score: 0.984
Data Source: Reactome,STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.984
Data Source: STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  1260.08

PubMed score by year
PubTator Score  1419.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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