Tchem HSPB1 Heat shock protein beta-1

Protein Summary

Description

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P04792
• B2R4N8
• Q6FI47
• Q96C20
• Q96EI7
• Q9UC31
• Q9UC34
• Q9UC35
• Q9UC36
• HspB1

Gene Name

• HSPB1

Ensembl ID

• ENST00000248553
• ENSP00000248553
• ENSG00000106211

Symbol

• HSP27
• HSP28
• CMT2F
• HMN2B
• HSP27
• HSP28
• Hsp25
• SRP27
• HS.76067
• HEL-S-102

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
interacting protein	1
hub protein	0.99
kinase	0.99
PubMedID	0.98

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1374.88   (req: < 5)

Gene RIFs: 470   (req: <= 3)

Antibodies: 2874   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1374.88   (req: >= 5)

Gene RIFs: 470   (req: > 3)

Antibodies: 2874   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0