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Tbio
MT1E
Metallothionein-1E

Protein Summary
Description
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306061
  • ENSP00000307706
  • ENSG00000169715
  • ENST00000330439
  • ENSP00000328137

Symbol
  • MT1
  • MTD
  • MT-1E
  • MT-IE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
small molecule perturbation
0.78
protein domain
0.73
PubMedID
0.54
histone modification site profile
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.97   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.97   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
metallothionein-1
100686073
Species
Name
OMA
EggNOG
Inparanoid
Dog
metallothionein-1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P04732-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Metallothioneins bind metals
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Metallothioneins bind metals
Response to metal ions
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
MT1M
Tbio
Novelty: 0.02649699
p_int: 0.988449263
p_ni: 1e-9
p_wrong: 0.011550737
Score: 0.7
Data Source: BioPlex,STRINGDB
MT1H
Tbio
Novelty: 0.01220609
Score: 0.831
Data Source: STRINGDB
MT1X
Tbio
Novelty: 0.03005906
Score: 0.83
Data Source: STRINGDB
MT2A
Tbio
Novelty: 0.00151469
Score: 0.812
Data Source: STRINGDB
MT1G
Tbio
Novelty: 0.02173544
Score: 0.784
Data Source: STRINGDB
MTF1
Tbio
Family: TF
Novelty: 0.01350821
Score: 0.742
Data Source: STRINGDB
MT1F
Tbio
Novelty: 0.03838808
Score: 0.728
Data Source: STRINGDB
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
Score: 0.705
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.691
Data Source: STRINGDB
ATOX1
Tbio
Novelty: 0.00509938
Score: 0.611
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.97

PubMed score by year
PubTator Score  196.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer