Protein Summary
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]
- ENST00000290705
- ENSP00000290705
- ENSG00000205362
- MT1S
- MT1
- MTC
- MT1S
- MT-1A
- MT-IA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.93 | ||
protein domain | 0.73 | ||
chemical | 0.68 | ||
cell type or tissue | 0.63 | ||
biological term | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 165.46 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 165.46 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (62)
Nearest Tclin Targets
Pathways (40)
Reactome (3)
KEGG (1)
WikiPathways (36)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Metallothioneins bind metals | ||||
Reactome | Response to metal ions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Metallothioneins bind metals | ||||
Response to metal ions | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 4 | 13 | 14 | 98.3 | |||||
apolipoprotein A 1 measurement | 2 | 9 | 9 | 96.9 | |||||
sleep duration | 2 | 3 | 3 | 63.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 14 | 98.3 | |||||
apolipoprotein A 1 measurement | 9 | 96.9 | |||||
sleep duration | 3 | 63.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | metallothionein 1A | VGNC:13736 | 100609521 | |||||
Cow | metallothionein 1E | 768319 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | metallothionein 1A | |||||
Cow | metallothionein 1E | |||||
Publication Statistics
PubMed Score 165.46
PubMed score by year
PubTator Score 100.62
PubTator score by year
Related Publications
Text Mined References (77)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
|---|