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Tchem
TP53
Cellular tumor antigen p53

Protein Summary
Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269305
  • ENSP00000269305
  • ENSG00000141510
  • ENST00000420246
  • ENSP00000391127
  • ENST00000445888
  • ENSP00000391478
  • ENST00000455263
  • ENSP00000398846
  • ENST00000504290
  • ENSP00000484409
  • ENST00000504937
  • ENSP00000481179
  • ENST00000510385
  • ENSP00000478499
  • ENST00000610292
  • ENSP00000478219
  • ENST00000610538
  • ENSP00000480868
  • ENST00000617185
  • ENSP00000482258
  • ENST00000619485
  • ENSP00000482537
  • ENST00000620739
  • ENSP00000481638
  • ENST00000622645
  • ENSP00000482222

Symbol
  • P53
  • P53
  • BCC7
  • LFS1
  • BMFS5
  • TRP53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59503.16   (req: < 5)
Gene RIFs: 9400   (req: <= 3)
Antibodies: 8417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59503.16   (req: >= 5)
Gene RIFs: 9400   (req: > 3)
Antibodies: 8417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 110
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0