TP53
Cellular tumor antigen p53
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of BH3-only proteins | ||||
Reactome | Activation of NOXA and translocation to mitochondria | ||||
Reactome | Activation of PUMA and translocation to mitochondria | ||||
Reactome | Apoptosis | ||||
Reactome | Association of TriC/CCT with target proteins during biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of BH3-only proteins | ||||
Activation of NOXA and translocation to mitochondria | ||||
Activation of PUMA and translocation to mitochondria | ||||
Apoptosis | ||||
Association of TriC/CCT with target proteins during biosynthesis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 10 | 25 | 35 | 100 | |||||
sex hormone-binding globulin measurement | 8 | 8 | 21 | 99.7 | |||||
hormone measurement | 2 | 3 | 1 | 57 | 94.8 | ||||
serum non-albumin protein measurement | 1 | 7 | 7 | 93.9 | |||||
4 | 2 | 0 | 2.6 | 91.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 35 | 100 | |||||
sex hormone-binding globulin measurement | 21 | 99.7 | |||||
hormone measurement | 1 | 57 | 94.8 | ||||
serum non-albumin protein measurement | 7 | 93.9 | |||||
0 | 2.6 | 91.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tumor protein p53 | VGNC:9734 | 455214 | |||||
Macaque | tumor protein p53 | 716170 | ||||||
Mouse | MGI:98834 | 22059 | ||||||
Rat | RGD:3889 | 24842 | ||||||
Dog | tumor protein p53 | VGNC:47719 | 403869 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tumor protein p53 | |||||
Macaque | tumor protein p53 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tumor protein p53 | |||||
PMID | Year | Title |
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