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Tchem
TP53
Cellular tumor antigen p53

Protein Summary
Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269305
  • ENSP00000269305
  • ENSG00000141510
  • ENST00000420246
  • ENSP00000391127
  • ENST00000445888
  • ENSP00000391478
  • ENST00000455263
  • ENSP00000398846
  • ENST00000504290
  • ENSP00000484409
  • ENST00000504937
  • ENSP00000481179
  • ENST00000510385
  • ENSP00000478499
  • ENST00000610292
  • ENSP00000478219
  • ENST00000610538
  • ENSP00000480868
  • ENST00000617185
  • ENSP00000482258
  • ENST00000619485
  • ENSP00000482537
  • ENST00000620739
  • ENSP00000481638
  • ENST00000622645
  • ENSP00000482222

Symbol
  • P53
  • P53
  • BCC7
  • LFS1
  • BMFS5
  • TRP53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55566.64   (req: < 5)
Gene RIFs: 7632   (req: <= 3)
Antibodies: 8417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55566.64   (req: >= 5)
Gene RIFs: 7632   (req: > 3)
Antibodies: 8417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 110
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1
0
2.1
97
4
2
0
2.6
95.8
3
2
0
2.8
95.6
appendicular lean mass
1
1
1
91.1
5
1
0
2.7
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.1
97
0
2.6
95.8
0
2.8
95.6
appendicular lean mass
1
91.1
0
2.7
90.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53
VGNC:9734
455214
Macaque
tumor protein p53
716170
Mouse
MGI:98834
22059
Rat
RGD:3889
24842
Dog
tumor protein p53
VGNC:47719
403869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53
Macaque
tumor protein p53
Mouse
Rat
Dog
tumor protein p53
Protein Data Bank (170)
1 – 5 of 170
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (210)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of NOXA and translocation to mitochondria
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Apoptosis
Association of TriC/CCT with target proteins during biosynthesis
Gene Ontology Terms (124)
Items per page:
10
1 – 10 of 34
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (1985)
1 – 10 of 1985
MDM4
Tchem
Novelty: 0.00321558
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CUL9
Tbio
Novelty: 0.1104365
p_int: 0.999999972
p_ni: 1.7e-8
p_wrong: 1.1e-8
Score: 0.681
Data Source: BioPlex,STRINGDB
CUL7
Tbio
Novelty: 0.02183958
p_int: 0.999991499
p_ni: 0.000008501
Score: 0.661
Data Source: BioPlex,STRINGDB
FBXW7
Tbio
Novelty: 0.00180856
p_int: 0.999684998
p_ni: 0.000315002
Score: 0.856
Data Source: BioPlex,STRINGDB
CELA2B
Tdark
Family: Enzyme
Novelty: 0.43122129
p_int: 0.995715315
p_ni: 0.004284685
Score: 0.542
Data Source: BioPlex,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
p_int: 0.988675145
p_ni: 0.011324855
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FAM111A
Tbio
Novelty: 0.06507063
p_int: 0.952013352
p_ni: 0.047986648
Score: 0.403
Data Source: BioPlex,STRINGDB
MZF1
Tbio
Family: TF
Novelty: 0.01193919
p_int: 0.938674001
p_ni: 0.061325997
p_wrong: 2e-9
Score: 0.259
Data Source: BioPlex,STRINGDB
HNF4A
Tchem
Family: NR
Novelty: 0.00041409
p_int: 0.907107395
p_ni: 0.092892605
Score: 0.737
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.895481844
p_ni: 0.104518156
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  55566.64

PubMed score by year
PubTator Score  38146.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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