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Tbio
CAPNS1
Calpain small subunit 1

Protein Summary
Description
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246533
  • ENSP00000246533
  • ENSG00000126247
  • ENST00000588815
  • ENSP00000464849

Symbol
  • CAPN4
  • CAPNS
  • CANP
  • CDPS
  • CSS1
  • CANPS
  • CAPN4
  • CALPAIN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor binding site profile
0.93
interacting protein
0.87
transcription factor perturbation
0.74
PubMedID
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.61   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.61   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999964866
p_ni:  0.000035134
Score:  0.947
Data Source:  BioPlex,Reactome,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.996177045
p_ni:  0.003822954
p_wrong:  1e-9
Score:  0.948
Data Source:  BioPlex,Reactome,STRINGDB
TNF
Tclin
Novelty:  0.00001457
p_int:  0.960139914
p_ni:  0.039860086
Score:  0.328
Data Source:  BioPlex,STRINGDB
CAPNS2
Tbio
Novelty:  0.45658116
p_int:  0.910442414
p_ni:  0.089557586
Score:  0.92
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.851967479
p_ni:  0.148032521
Data Source:  BioPlex
CAST
Tbio
Novelty:  0.00099404
Score:  0.982
Data Source:  Reactome,STRINGDB
CAPN7
Tbio
Novelty:  0.03088521
Score:  0.967
Data Source:  STRINGDB
CAPN5
Tbio
Novelty:  0.02614694
Score:  0.967
Data Source:  STRINGDB
CAPN6
Tbio
Novelty:  0.04489237
Score:  0.967
Data Source:  STRINGDB
CAPN10
Tbio
Novelty:  0.00497347
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Developmental Biology
Reactome
Disease
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Developmental Biology
Disease
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
neutrophil percentage of leukocytes
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
neutrophil percentage of leukocytes
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain small subunit 1
VGNC:7550
455975
Macaque
calpain small subunit 1
712561
Mouse
MGI:88266
12336
Rat
RGD:2270
29156
Dog
calpain small subunit 1
VGNC:53676
611746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain small subunit 1
Macaque
calpain small subunit 1
Mouse
Rat
Dog
calpain small subunit 1
Publication Statistics
PubMed Score 117.61
PubMed score by year
PubTator Score 41.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title