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Tclin
NTRK1
High affinity nerve growth factor receptor

Protein Summary
Description
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368196
  • ENSP00000357179
  • ENSG00000198400
  • ENST00000392302
  • ENSP00000376120
  • ENST00000524377
  • ENSP00000431418

Symbol
  • MTC
  • TRK
  • TRKA
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
hub protein
0.99
biological term
0.96


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2182.11   (req: < 5)
Gene RIFs: 208   (req: <= 3)
Antibodies: 1414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2182.11   (req: >= 5)
Gene RIFs: 208   (req: > 3)
Antibodies: 1414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1065
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Active Ligands (1065)
1 – 10 of 1065
CHEMBL388978
chemical structure image
CHEMBL603469
chemical structure image
CHEMBL1230609
chemical structure image
CHEMBL1908395,CHEMBL1908842
chemical structure image
CHEMBL2151321
chemical structure image
CHEMBL3128069
chemical structure image
CHEMBL1822792
chemical structure image
DDR1/2 inhibitor 5n
chemical structure image
sitravatinib
chemical structure image
CHEMBL2010872
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
61.2
red blood cell distribution width
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
61.2
red blood cell distribution width
1
16.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurotrophic receptor tyrosine kinase 1
719670
Mouse
MGI:97383
18211
Rat
RGD:620144
59109
Dog
neurotrophic receptor tyrosine kinase 1
VGNC:44011
490404
Horse
neurotrophic receptor tyrosine kinase 1
VGNC:20926
100064594
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurotrophic receptor tyrosine kinase 1
Mouse
Rat
Dog
neurotrophic receptor tyrosine kinase 1
Horse
neurotrophic receptor tyrosine kinase 1
Protein Data Bank (38)
1 – 5 of 38
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (151)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Activation of TRKA receptors
Reactome
Frs2-mediated activation
Reactome
NGF-independant TRKA activation
Reactome
PI3K/AKT activation
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Activation of TRKA receptors
Frs2-mediated activation
NGF-independant TRKA activation
PI3K/AKT activation
Gene Ontology Terms (73)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (273)
1 – 10 of 273
NGF
Tchem
Novelty: 0.00008139
Score: 0.999
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.998
Data Source: Reactome,STRINGDB
NTF3
Tbio
Novelty: 0.00089023
Score: 0.996
Data Source: STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.994
Data Source: STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.991
Data Source: STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.99
Data Source: Reactome,STRINGDB
SHC3
Tbio
Novelty: 0.03638847
Score: 0.988
Data Source: Reactome,STRINGDB
SHC2
Tbio
Novelty: 0.00219395
Score: 0.985
Data Source: Reactome,STRINGDB
GIPC1
Tbio
Novelty: 0.00862
Score: 0.977
Data Source: STRINGDB
RGS19
Tchem
Novelty: 0.0159403
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  2182.11

PubMed score by year
PubTator Score  993.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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