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Tclin
ERBB2
Receptor tyrosine-protein kinase erbB-2

Protein Summary
Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269571
  • ENSP00000269571
  • ENSG00000141736
  • ENST00000406381
  • ENSP00000385185
  • ENST00000541774
  • ENSP00000446466
  • ENST00000584601
  • ENSP00000462438

Symbol
  • HER2
  • MLN19
  • NEU
  • NGL
  • NEU
  • NGL
  • HER2
  • TKR1
  • CD340
  • HER-2
  • MLN 19
  • HER-2/neu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36767.78   (req: < 5)
Gene RIFs: 2521   (req: <= 3)
Antibodies: 5131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36767.78   (req: >= 5)
Gene RIFs: 2521   (req: > 3)
Antibodies: 5131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 452
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16