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Tbio
PRM2
Protamine-2

Protein Summary
Description
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241808
  • ENSP00000241808
  • ENSG00000122304
  • ENST00000435245
  • ENSP00000403681

Symbol
  • CT94.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.65
tissue
0.52
co-expressed gene
0.44
cell line
0.42
PubMedID
0.39


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.53   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.53   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protamine 2
VGNC:5892
453921
Macaque
protamine 2
711424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protamine 2
Macaque
protamine 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (102)
1 – 10 of 102
RBM27
Tdark
Novelty: 0.04875536
p_int: 0.999998079
p_ni: 0.000001921
Data Source: BioPlex
CHCHD2
Tbio
Novelty: 0.01615338
p_int: 0.999997642
p_ni: 0.000002357
p_wrong: 1e-9
Data Source: BioPlex
RBM23
Tbio
Novelty: 0.03769792
p_int: 0.999994662
p_ni: 0.000005338
Data Source: BioPlex
PHF10
Tbio
Family: Epigenetic
Novelty: 0.05941323
p_int: 0.999973537
p_ni: 0.000026463
Data Source: BioPlex
ZNF579
Tdark
Family: TF
Novelty: 4.75515836
p_int: 0.999956812
p_ni: 0.000043187
p_wrong: 1e-9
Data Source: BioPlex
YY1AP1
Tbio
Novelty: 0.06862573
p_int: 0.999845049
p_ni: 0.000154929
p_wrong: 2.2e-8
Data Source: BioPlex
LTV1
Tbio
Novelty: 0.04050879
p_int: 0.999832657
p_ni: 0.000167343
Data Source: BioPlex
PSME3
Tbio
Novelty: 0.01051254
p_int: 0.999824386
p_ni: 0.000175614
Data Source: BioPlex
SCAF4
Tbio
Novelty: 0.08174395
p_int: 0.999806599
p_ni: 0.000193401
Data Source: BioPlex
ZNF638
Tbio
Novelty: 0.13248064
p_int: 0.999692853
p_ni: 0.000307147
Data Source: BioPlex
Publication Statistics
PubMed Score  196.53

PubMed score by year
PubTator Score  115.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer