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Tbio
HLA-DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399500
  • ENSP00000382422
  • ENSG00000215048
  • ENST00000411749
  • ENSP00000414196
  • ENSG00000236693
  • ENST00000418931
  • ENSP00000408146
  • ENSG00000223865
  • ENST00000425130
  • ENSP00000396095
  • ENSG00000230763
  • ENST00000433800
  • ENSP00000407674
  • ENSG00000226826
  • ENST00000454006
  • ENSP00000389288
  • ENSG00000237710

Symbol
  • HLA-DP1B
  • DPB1
  • HLA-DP
  • HLA-DPB
  • HLA-DP1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
protein domain
0.92
disease
0.89
biological term
0.87
trait
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.99   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 547   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.99   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 547   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (139)
Items per page:
1 – 5 of 139
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis B virus infection
4
2
0
1.6
99.3
chronic hepatitis B virus infection
4
2
0
1.6
99.3
chronic hepatitis B virus infection
4
2
0
1.6
99.3
chronic hepatitis B virus infection
4
2
0
1.6
99.3
chronic hepatitis B virus infection
4
2
0
1.6
99.3
Items per page:
1 – 5 of 139
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis B virus infection
0
1.6
99.3
chronic hepatitis B virus infection
0
1.6
99.3
chronic hepatitis B virus infection
0
1.6
99.3
chronic hepatitis B virus infection
0
1.6
99.3
chronic hepatitis B virus infection
0
1.6
99.3
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (68)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (310)
1 – 10 of 310
LYRM4
Tbio
Novelty: 0.03319832
p_int: 0.999819057
p_ni: 0.000033578
p_wrong: 0.000147365
Score: 0.187
Data Source: BioPlex,STRINGDB
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.959645296
p_ni: 0.04035467
p_wrong: 3.4e-8
Data Source: BioPlex
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.958346179
p_ni: 0.041653821
Score: 0.995
Data Source: BioPlex,STRINGDB
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.952616583
p_ni: 0.047382812
p_wrong: 6.06e-7
Data Source: BioPlex
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.951056291
p_ni: 0.048943709
Data Source: BioPlex
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.945866714
p_ni: 0.054133285
p_wrong: 2e-9
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.935924173
p_ni: 0.064075827
Data Source: BioPlex
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.935050369
p_ni: 0.064949631
Score: 0.187
Data Source: BioPlex,STRINGDB
RARRES2
Tbio
Novelty: 0.0029178
p_int: 0.875848957
p_ni: 0.124151032
p_wrong: 1.1e-8
Data Source: BioPlex
GCNT2
Tbio
Family: Enzyme
Novelty: 0.03945461
p_int: 0.839202841
p_ni: 0.160790997
p_wrong: 0.000006162
Data Source: BioPlex
Publication Statistics
PubMed Score  908.99

PubMed score by year
PubTator Score  883.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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