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Tchem
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase

Protein Summary
Description
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibitio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229239
  • ENSP00000229239
  • ENSG00000111640
  • ENST00000396858
  • ENSP00000380067
  • ENST00000396859
  • ENSP00000380068
  • ENST00000396861
  • ENSP00000380070
  • ENST00000619601
  • ENSP00000478864

Symbol
  • GAPD
  • G3PD
  • GAPD
  • HEL-S-162eP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
chemical
0.96
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11350.59   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 2468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11350.59   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 2468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (1596)
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.999999808
p_ni:  1.75e-7
p_wrong:  1.7e-8
Score:  0.844
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.993715189
p_ni:  0.006284811
Score:  0.595
Data Source:  BioPlex,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.913290897
p_ni:  0.086709103
Score:  0.211
Data Source:  BioPlex,STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.769814755
p_ni:  0.230185245
Score:  0.378
Data Source:  BioPlex,STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.999
Data Source:  STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.998
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.995
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.995
Data Source:  STRINGDB
RPL13A
Tbio
Novelty:  0.00503698
Score:  0.99
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
67.1
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
heel bone mineral density
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
67.1
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
heel bone mineral density
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glyceraldehyde-3-phosphate dehydrogenase
VGNC:5396
451783
Macaque
glyceraldehyde-3-phosphate dehydrogenase
574353
Dog
glyceraldehyde-3-phosphate dehydrogenase-like
100688969
Cow
glyceraldehyde-3-phosphate dehydrogenase
281181
Chicken
glyceraldehyde-3-phosphate dehydrogenase
CGNC:49077
374193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glyceraldehyde-3-phosphate dehydrogenase
Macaque
glyceraldehyde-3-phosphate dehydrogenase
Dog
glyceraldehyde-3-phosphate dehydrogenase-like
Cow
glyceraldehyde-3-phosphate dehydrogenase
Chicken
glyceraldehyde-3-phosphate dehydrogenase
Publication Statistics
PubMed Score 11350.59
PubMed score by year
PubTator Score 2556.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title