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Tclin
TUBB4A
Tubulin beta-4A chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264071
  • ENSP00000264071
  • ENSG00000104833

Symbol
  • TUBB4
  • TUBB5
  • DYT4
  • TUBB4
  • beta-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.97
protein domain
0.97
molecular function
0.94
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.93   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.93   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Pathways (34)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Carboxyterminal post-translational modifications of tubulin
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (279)
1 – 10 of 279
CAPS
Tbio
Novelty: 0.04750104
p_int: 0.994474562
p_ni: 0.005525438
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.04716423
p_int: 0.990868899
p_ni: 0.009131101
Data Source: BioPlex
LRP1
Tbio
Novelty: 0.00117899
p_int: 0.954402333
p_ni: 0.045597667
Score: 0.151
Data Source: BioPlex,STRINGDB
MFAP5
Tbio
Novelty: 0.02976267
p_int: 0.93130416
p_ni: 0.06869584
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.08368201
p_int: 0.925355401
p_ni: 0.074644598
Data Source: BioPlex
TPSB2
Tbio
Family: Enzyme
Novelty: 0.01241014
p_int: 0.922143571
p_ni: 0.077856429
Data Source: BioPlex
FAS
Tbio
Novelty: 0.00049744
p_int: 0.914062523
p_ni: 0.085937477
Score: 0.152
Data Source: BioPlex,STRINGDB
TUBB
Tclin
Novelty: 0.00489923
p_int: 0.907822726
p_ni: 0.092177274
Score: 0.92
Data Source: BioPlex,STRINGDB
DNAL4
Tdark
Novelty: 0.2970297
p_int: 0.872287074
p_ni: 0.127712926
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.10472842
p_int: 0.87036905
p_ni: 0.12963095
Data Source: BioPlex
Publication Statistics
PubMed Score  965.93

PubMed score by year
PubTator Score  86.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer