Protein Classes
Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
- ENST00000264071
- ENSP00000264071
- ENSG00000104833
- TUBB4
- TUBB5
- DYT4
- TUBB4
- beta-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 0.99 | ||
interacting protein | 0.97 | ||
protein domain | 0.97 | ||
molecular function | 0.94 | ||
gene perturbation | 0.71 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.93 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.93 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Approved Drugs (13)
1 – 10 of 13
Pathways (34)
Reactome (25)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 25
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Carboxyterminal post-translational modifications of tubulin | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Gene Ontology Terms (20)
Functions (4)
Components (9)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (279)
1 – 10 of 279
CAPS
Novelty: 0.04750104
p_int: 0.994474562
p_ni: 0.005525438
Data Source: BioPlex
OSTM1
Novelty: 0.04716423
p_int: 0.990868899
p_ni: 0.009131101
Data Source: BioPlex
LRP1
Novelty: 0.00117899
p_int: 0.954402333
p_ni: 0.045597667
Score: 0.151
Data Source: BioPlex,STRINGDB
MFAP5
Novelty: 0.02976267
p_int: 0.93130416
p_ni: 0.06869584
Data Source: BioPlex
GLMP
Novelty: 0.08368201
p_int: 0.925355401
p_ni: 0.074644598
Data Source: BioPlex
TPSB2
Family: Enzyme
Novelty: 0.01241014
p_int: 0.922143571
p_ni: 0.077856429
Data Source: BioPlex
FAS
Novelty: 0.00049744
p_int: 0.914062523
p_ni: 0.085937477
Score: 0.152
Data Source: BioPlex,STRINGDB
TUBB
Novelty: 0.00489923
p_int: 0.907822726
p_ni: 0.092177274
Score: 0.92
Data Source: BioPlex,STRINGDB
DNAL4
Novelty: 0.2970297
p_int: 0.872287074
p_ni: 0.127712926
Data Source: BioPlex
ISLR
Novelty: 0.10472842
p_int: 0.87036905
p_ni: 0.12963095
Data Source: BioPlex
Publication Statistics
PubMed Score 965.93
PubMed score by year
PubTator Score 86.76
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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