Tclin TUBB4A Tubulin beta-4A chain

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-4a Chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P04350
• B3KQP4
• Q969E5

Gene Name

• TUBB4A

Ensembl ID

• ENST00000264071
• ENSP00000264071
• ENSG00000104833

Symbol

• TUBB4
• TUBB5
• DYT4
• TUBB4
• beta-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
interacting protein	0.97
protein domain	0.97
molecular function	0.94
gene perturbation	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.93   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.93   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13

Approved Drugs (13)

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1 – 10 of 13

paclitaxel

TUBB4ATclin

INHIBITOR EC50: 8.05

vinblastine

TUBB4ATclin

INHIBITOR IC50: 9

docetaxel

TUBB4ATclin

INHIBITOR ID50: 6.69899988

trastuzumab emtansine

TUBB4ATclin

INHIBITOR :

brentuximab vedotin

TUBB4ATclin

INHIBITOR :

eribulin

TUBB4ATclin

INHIBITOR IC50: 8.22999954

vinorelbine

TUBB4ATclin

INHIBITOR :

polatuzumab vedotin

TUBB4ATclin

BINDING AGENT :

enfortumab vedotin

TUBB4ATclin

BINDING AGENT :

vincristine

TUBB4ATclin

INHIBITOR :

Pathways (34)

Reactome (25)

KEGG (3)

PathwayCommons (2)

WikiPathways (4)

AURKA Activation by TPX2 (R-HSA-8854518)

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5

1 – 5 of 25

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Gene Ontology Terms (20)

Functions (4)

Components (9)

Processes (7)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Mutant Phenotype (IMP)	CAFA
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (279)

Explore Interacting Targets

1 – 10 of 279

• See Interactions on String-DB

CAPS

Tbio

Novelty: 0.04750104

p_int: 0.994474562

p_ni: 0.005525438

Data Source: BioPlex

OSTM1

Tbio

Novelty: 0.04716423

p_int: 0.990868899

p_ni: 0.009131101

Data Source: BioPlex

LRP1

Tbio

Novelty: 0.00117899

p_int: 0.954402333

p_ni: 0.045597667

Score: 0.151

Data Source: BioPlex,STRINGDB

MFAP5

Tbio

Novelty: 0.02976267

p_int: 0.93130416

p_ni: 0.06869584

Data Source: BioPlex

GLMP

Tdark

Novelty: 0.08368201

p_int: 0.925355401

p_ni: 0.074644598

Data Source: BioPlex

TPSB2

Tbio

Family: Enzyme

Novelty: 0.01241014

p_int: 0.922143571

p_ni: 0.077856429

Data Source: BioPlex

FAS

Tbio

Novelty: 0.00049744

p_int: 0.914062523

p_ni: 0.085937477

Score: 0.152

Data Source: BioPlex,STRINGDB

TUBB

Tclin

Novelty: 0.00489923

p_int: 0.907822726

p_ni: 0.092177274

Score: 0.92

Data Source: BioPlex,STRINGDB

DNAL4

Tdark

Novelty: 0.2970297

p_int: 0.872287074

p_ni: 0.127712926

Data Source: BioPlex

ISLR

Tbio

Novelty: 0.10472842

p_int: 0.87036905

p_ni: 0.12963095

Data Source: BioPlex

Publication Statistics

PubMed Score  965.93

PubMed score by year

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PubTator Score  86.76

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Dystonia
GTP-binding
Isopeptide bond
Leukodystrophy
Microtubule

GWAS Trait Find Similar Targets

asthma