Tbio SEMG1 Semenogelin-1

Protein Summary

Description

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P04279
• Q53ZV0
• Q53ZV1
• Q53ZV2
• Q6X4I9
• Q6Y809
• Q6Y822
• Q6Y823
• Q86U64
• Q96QM3

Gene Name

• SEMG1

Ensembl ID

• ENST00000372781
• ENSP00000361867
• ENSG00000124233

Symbol

• SEMG
• SGI
• SEMG
• CT103
• dJ172H20.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.75
cell line	0.58
cellular component	0.58
biological term	0.55
chemical	0.45

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.82   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.82   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P04279-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)

Reactome (5)

Amyloid fiber formation (R-HSA-977225)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (18)

Functions (1)

Components (5)

Processes (12)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion binding	Inferred from Mutant Phenotype (IMP)	UniProtKB

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

TXNDC16

Tdark

Novelty: 0.25365147

p_int: 0.999999535

p_ni: 4.65e-7

Data Source: BioPlex

DLX6

Tbio

Family: TF

Novelty: 0.01455012

p_int: 0.999999371

p_ni: 6.29e-7

Data Source: BioPlex

NUPR1

Tbio

Novelty: 0.00934603

p_int: 0.999998128

p_ni: 0.000001872

Score: 0.209

Data Source: BioPlex,STRINGDB

LSM14B

Tdark

Novelty: 0.31832554

p_int: 0.99999635

p_ni: 0.00000365

Score: 0.177

Data Source: BioPlex,STRINGDB

MSS51

Tbio

Novelty: 0.06388791

p_int: 0.999995575

p_ni: 0.000004425

Score: 0.209

Data Source: BioPlex,STRINGDB

FTH1

Tbio

Novelty: 0.000863

p_int: 0.999986264

p_ni: 0.000013736

Data Source: BioPlex

POLL

Tbio

Family: Enzyme

Novelty: 0.00244645

p_int: 0.999976911

p_ni: 0.000023089

Data Source: BioPlex

SYT16

Tbio

Novelty: 0.05270686

p_int: 0.999969087

p_ni: 0.000030913

Score: 0.183

Data Source: BioPlex,STRINGDB

HACD1

Tbio

Family: Enzyme

Novelty: 0.02323512

p_int: 0.999950756

p_ni: 0.000049244

Score: 0.295

Data Source: BioPlex,STRINGDB

C9orf139

Tdark

Novelty: 1.54653983

p_int: 0.999911256

p_ni: 0.000088744

Score: 0.187

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  62.82

PubMed score by year

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PubTator Score  191.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Secreted
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