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Tbio
SEMG1
Semenogelin-1

Protein Summary
Description
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.75
cell line
0.58
cellular component
0.58
biological term
0.55
chemical
0.45


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.82   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.82   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P04279-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Antimicrobial peptides
Immune System
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (63)
1 – 10 of 63
TXNDC16
Tdark
Novelty: 0.25365147
p_int: 0.999999535
p_ni: 4.65e-7
Data Source: BioPlex
DLX6
Tbio
Family: TF
Novelty: 0.01455012
p_int: 0.999999371
p_ni: 6.29e-7
Data Source: BioPlex
NUPR1
Tbio
Novelty: 0.00934603
p_int: 0.999998128
p_ni: 0.000001872
Score: 0.209
Data Source: BioPlex,STRINGDB
LSM14B
Tdark
Novelty: 0.31832554
p_int: 0.99999635
p_ni: 0.00000365
Score: 0.177
Data Source: BioPlex,STRINGDB
MSS51
Tbio
Novelty: 0.06388791
p_int: 0.999995575
p_ni: 0.000004425
Score: 0.209
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.000863
p_int: 0.999986264
p_ni: 0.000013736
Data Source: BioPlex
POLL
Tbio
Family: Enzyme
Novelty: 0.00244645
p_int: 0.999976911
p_ni: 0.000023089
Data Source: BioPlex
SYT16
Tbio
Novelty: 0.05270686
p_int: 0.999969087
p_ni: 0.000030913
Score: 0.183
Data Source: BioPlex,STRINGDB
HACD1
Tbio
Family: Enzyme
Novelty: 0.02323512
p_int: 0.999950756
p_ni: 0.000049244
Score: 0.295
Data Source: BioPlex,STRINGDB
C9orf139
Tdark
Novelty: 1.54653983
p_int: 0.999911256
p_ni: 0.000088744
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.82

PubMed score by year
PubTator Score  191.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer