Protein Summary
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows ...more
- ENST00000372781
- ENSP00000361867
- ENSG00000124233
- SEMG
- SGI
- SEMG
- CT103
- dJ172H20.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.75 | ||
cell line | 0.58 | ||
cellular component | 0.58 | ||
biological term | 0.55 | ||
chemical | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.66 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.66 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (63)
NUPR1
Novelty: 0.00934603
p_int: 0.999998128
p_ni: 0.000001872
Score: 0.209
Data Source: BioPlex,STRINGDB
LSM14B
Novelty: 0.31832554
p_int: 0.99999635
p_ni: 0.00000365
Score: 0.177
Data Source: BioPlex,STRINGDB
MSS51
Novelty: 0.06388791
p_int: 0.999995575
p_ni: 0.000004425
Score: 0.209
Data Source: BioPlex,STRINGDB
POLL
Family: Enzyme
Novelty: 0.00244645
p_int: 0.999976911
p_ni: 0.000023089
Data Source: BioPlex
SYT16
Novelty: 0.05270686
p_int: 0.999969087
p_ni: 0.000030913
Score: 0.183
Data Source: BioPlex,STRINGDB
HACD1
Family: Enzyme
Novelty: 0.02323512
p_int: 0.999950756
p_ni: 0.000049244
Score: 0.295
Data Source: BioPlex,STRINGDB
C9orf139
Novelty: 1.54653983
p_int: 0.999911256
p_ni: 0.000088744
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (5)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 3.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 3.1 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 63.66
PubMed score by year
PubTator Score 191.52
PubTator score by year
Related Publications
Text Mined References (64)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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