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Tbio
VWF
von Willebrand factor

Protein Summary
Description
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261405
  • ENSP00000261405
  • ENSG00000110799

Symbol
  • F8VWF
  • VWD
  • F8VWF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
viral protein
1
PubMedID
0.95
protein domain
0.92
cellular component
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11646.96   (req: < 5)
Gene RIFs: 715   (req: <= 3)
Antibodies: 1819   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11646.96   (req: >= 5)
Gene RIFs: 715   (req: > 3)
Antibodies: 1819   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
3
3
2
3.9
97.9
factor VIII measurement
2
3
3
2.6
96.2
venous thromboembolism
2
1
1
1.1
84.3
coagulation factor measurement
1
1
1
78.1
mean platelet volume
2
2
3
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
3.9
97.9
factor VIII measurement
3
2.6
96.2
venous thromboembolism
1
1.1
84.3
coagulation factor measurement
1
78.1
mean platelet volume
3
69.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor
VGNC:5646
451773
Mouse
MGI:98941
22371
Dog
von Willebrand factor
VGNC:48329
399544
Horse
von Willebrand factor
VGNC:24961
100059472
Opossum
von Willebrand factor
100014453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor
Mouse
Dog
von Willebrand factor
Horse
von Willebrand factor
Opossum
von Willebrand factor
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Formation of Fibrin Clot (Clotting Cascade)
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (425)
1 – 10 of 425
F8
Tbio
Novelty: 0.0002287
Score: 0.998
Data Source: Reactome,STRINGDB
GP1BA
Tbio
Novelty: 0.00138736
Score: 0.997
Data Source: Reactome,STRINGDB
ITGA2B
Tclin
Novelty: 0.00023168
Score: 0.989
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.986
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.985
Data Source: Reactome,STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.983
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.983
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.98
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.978
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  11646.96

PubMed score by year
PubTator Score  5685.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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