Protein Classes
Protein Summary
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucl ...more
- ENST00000291700
- ENSP00000291700
- ENSG00000160307
- ENST00000397648
- ENSP00000380769
- NEF
- S100
- S100-B
- S100beta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
pathway | 0.9 | ||
protein domain | 0.85 | ||
biological process | 0.79 | ||
chemical | 0.77 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3416.04 (req: < 5)
Gene RIFs: 321 (req: <= 3)
Antibodies: 1579 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3416.04 (req: >= 5)
Gene RIFs: 321 (req: > 3)
Antibodies: 1579 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (31)
Reactome (30)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 30
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Advanced glycosylation endproduct receptor signaling | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Advanced glycosylation endproduct receptor signaling | ||||
Cytokine Signaling in Immune system | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Immune System | ||||
Innate Immune System | ||||
Gene Ontology Terms (33)
Functions (8)
Components (7)
Processes (18)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (296)
1 – 10 of 296
MLLT11
Novelty: 0.04775712
p_int: 0.998038632
p_ni: 0.000068237
p_wrong: 0.001893131
Score: 0.692
Data Source: BioPlex,STRINGDB
LSM5
Novelty: 0.09756098
p_int: 0.986460925
p_ni: 0.003386382
p_wrong: 0.010152693
Score: 0.241
Data Source: BioPlex,STRINGDB
AGER
Novelty: 0.00062993
Score: 0.999
Data Source: STRINGDB
FGF2
Novelty: 0.00009754
Score: 0.975
Data Source: STRINGDB
APP
Novelty: 0.00011446
Score: 0.968
Data Source: STRINGDB
RPS6KA1
Family: Kinase
Novelty: 0.00250734
Score: 0.967
Data Source: STRINGDB
HMGB1
Family: TF
Novelty: 0.00050302
Score: 0.954
Data Source: STRINGDB
CAPZA1
Novelty: 0.04371834
Score: 0.95
Data Source: Reactome,STRINGDB
STK38
Family: Kinase
Novelty: 0.04129184
Score: 0.944
Data Source: STRINGDB
MAPK3
Family: Kinase
Novelty: 0.0001911
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score 3416.04
PubMed score by year
PubTator Score 3084.34
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECD
1-70
FQEFMAFVAMVTTACHEFFEHE
70-92
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE
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