Tchem S100B Protein S100-B

Protein Summary

Description

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04271
• D3DSN6

Gene Name

• S100B

Ensembl ID

• ENST00000291700
• ENSP00000291700
• ENSG00000160307
• ENST00000397648
• ENSP00000380769

Symbol

• NEF
• S100
• S100-B
• S100beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
pathway	0.9
protein domain	0.85
biological process	0.79
chemical	0.77

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3434.2   (req: < 5)

Gene RIFs: 321   (req: <= 3)

Antibodies: 1579   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3434.2   (req: >= 5)

Gene RIFs: 321   (req: > 3)

Antibodies: 1579   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

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Approved Drugs (1)

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pentamidine

S100BTchem

pKd : 6

Protein-Protein Interactions (296)

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• See Interactions on String-DB

MLLT11

Tbio

Novelty:  0.04243441

p_int:  0.998038632

p_ni:  0.000068237

p_wrong:  0.001893131

Score:  0.692

Data Source:  BioPlex,STRINGDB

LSM5

Tbio

Novelty:  0.12669584

p_int:  0.986460925

p_ni:  0.003386382

p_wrong:  0.010152693

Score:  0.241

Data Source:  BioPlex,STRINGDB

AGER

Tchem

Novelty:  0.00061101

Score:  0.999

Data Source:  STRINGDB

FGF2

Tchem

Novelty:  0.00007856

Score:  0.975

Data Source:  STRINGDB

APP

Tchem

Novelty:  0.00008964

Score:  0.968

Data Source:  STRINGDB

RPS6KA1

Tchem

Family:  Kinase

Novelty:  0.00178073

Score:  0.967

Data Source:  STRINGDB

HMGB1

Tchem

Family:  TF

Novelty:  0.00043845

Score:  0.954

Data Source:  STRINGDB

CAPZA1

Tbio

Novelty:  0.03448517

Score:  0.95

Data Source:  Reactome,STRINGDB

STK38

Tchem

Family:  Kinase

Novelty:  0.03242123

Score:  0.944

Data Source:  STRINGDB

MAPK3

Tchem

Family:  Kinase

Novelty:  0.00012969

Score:  0.938

Data Source:  STRINGDB

Pathways (31)

Reactome (30)

PathwayCommons (1)

Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Advanced glycosylation endproduct receptor signaling	13 targets	R-HSA-879415
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Advanced glycosylation endproduct receptor signaling	13 targets	R-HSA-879415
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (33)

Functions (8)

Components (7)

Processes (18)

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GO Term	Evidence	Assigned by
calcium-dependent protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
RAGE receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
S100 protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
tau protein binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
zinc ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
calcium ion binding	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (6)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	3	3		88.7
myeloid white cell count	EFO_0007988	1	1	1		72.9
neutrophil count	EFO_0004833	2	2	2		68.4
leukocyte count	EFO_0004308	1	1	1		65.9
pulse pressure measurement	EFO_0005763	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3		88.7
myeloid white cell count	EFO_0007988	1		72.9
neutrophil count	EFO_0004833	2		68.4
leukocyte count	EFO_0004308	1		65.9
pulse pressure measurement	EFO_0005763	1		49.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Metal-binding
Nucleus
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
leukocyte count
lymphocyte count
myeloid white cell count
neutrophil count
pulse pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
homeostasis/metabolism phenotype
integument phenotype

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	S100 calcium binding protein B	VGNC:1125	474141
Macaque	S100 calcium binding protein B		708117
Mouse	S100 protein, beta polypeptide, neural	MGI:98217	20203
Rat	S100 calcium binding protein B	RGD:3615	25742
Dog	S100 calcium binding protein B	VGNC:49642	491615

Species	Name	OMA	EggNOG	Inparanoid
Chimp	S100 calcium binding protein B
Macaque	S100 calcium binding protein B
Mouse	S100 protein, beta polypeptide, neural
Rat	S100 calcium binding protein B
Dog	S100 calcium binding protein B

Publication Statistics

PubMed Score 3434.20

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PubTator Score 3084.34

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