Protein Summary
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucl ...more
- ENST00000291700
- ENSP00000291700
- ENSG00000160307
- ENST00000397648
- ENSP00000380769
- NEF
- S100
- S100-B
- S100beta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
pathway | 0.9 | ||
protein domain | 0.85 | ||
biological process | 0.79 | ||
chemical | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3434.2 (req: < 5)
Gene RIFs: 321 (req: <= 3)
Antibodies: 1579 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3434.2 (req: >= 5)
Gene RIFs: 321 (req: > 3)
Antibodies: 1579 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (296)
MLLT11
Novelty: 0.04243441
p_int: 0.998038632
p_ni: 0.000068237
p_wrong: 0.001893131
Score: 0.692
Data Source: BioPlex,STRINGDB
LSM5
Novelty: 0.12669584
p_int: 0.986460925
p_ni: 0.003386382
p_wrong: 0.010152693
Score: 0.241
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (31)
Reactome (30)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Advanced glycosylation endproduct receptor signaling | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Advanced glycosylation endproduct receptor signaling | ||||
Cytokine Signaling in Immune system | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (8)
Components (7)
Processes (18)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 3 | 3 | 88.7 | |||||
myeloid white cell count | 1 | 1 | 1 | 72.9 | |||||
neutrophil count | 2 | 2 | 2 | 68.4 | |||||
leukocyte count | 1 | 1 | 1 | 65.9 | |||||
pulse pressure measurement | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 88.7 | |||||
myeloid white cell count | 1 | 72.9 | |||||
neutrophil count | 2 | 68.4 | |||||
leukocyte count | 1 | 65.9 | |||||
pulse pressure measurement | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein B | VGNC:1125 | 474141 | |||||
Macaque | S100 calcium binding protein B | 708117 | ||||||
Mouse | MGI:98217 | 20203 | ||||||
Rat | RGD:3615 | 25742 | ||||||
Dog | S100 calcium binding protein B | VGNC:49642 | 491615 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein B | |||||
Macaque | S100 calcium binding protein B | |||||
Mouse | ||||||
Rat | ||||||
Dog | S100 calcium binding protein B | |||||
Publication Statistics
PubMed Score 3434.20
PubMed score by year
PubTator Score 3084.34
PubTator score by year
Related Publications
Text Mined References (371)
GeneRif Annotations (321)
Items per page:
0 of 0
PMID | Year | Title |
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