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Tchem
S100B
Protein S100-B

Protein Summary
Description
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291700
  • ENSP00000291700
  • ENSG00000160307
  • ENST00000397648
  • ENSP00000380769

Symbol
  • NEF
  • S100
  • S100-B
  • S100beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
pathway
0.9
protein domain
0.85
biological process
0.79
chemical
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3345.98   (req: < 5)
Gene RIFs: 321   (req: <= 3)
Antibodies: 1579   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3345.98   (req: >= 5)
Gene RIFs: 321   (req: > 3)
Antibodies: 1579   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
pentamidine
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
7.5
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (296)
1 – 10 of 296
MLLT11
Tbio
Novelty: 0.04243441
p_int: 0.998038632
p_ni: 0.000068237
p_wrong: 0.001893131
Score: 0.692
Data Source: BioPlex,STRINGDB
LSM5
Tbio
Novelty: 0.12669584
p_int: 0.986460925
p_ni: 0.003386382
p_wrong: 0.010152693
Score: 0.241
Data Source: BioPlex,STRINGDB
AGER
Tchem
Novelty: 0.00061101
Score: 0.999
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.975
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.968
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.967
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.954
Data Source: STRINGDB
CAPZA1
Tbio
Novelty: 0.03448517
Score: 0.95
Data Source: Reactome,STRINGDB
STK38
Tbio
Family: Kinase
Novelty: 0.03242123
Score: 0.944
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  3345.98

PubMed score by year
PubTator Score  3084.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer