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Tchem
S100B
Protein S100-B

Protein Summary
Description
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291700
  • ENSP00000291700
  • ENSG00000160307
  • ENST00000397648
  • ENSP00000380769

Symbol
  • NEF
  • S100
  • S100-B
  • S100beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
pathway
0.9
protein domain
0.85
biological process
0.79
chemical
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3345.98   (req: < 5)
Gene RIFs: 321   (req: <= 3)
Antibodies: 1579   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3345.98   (req: >= 5)
Gene RIFs: 321   (req: > 3)
Antibodies: 1579   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
pentamidine
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
7.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein B
VGNC:1125
474141
Macaque
S100 calcium binding protein B
708117
Mouse
MGI:98217
20203
Rat
RGD:3615
25742
Dog
S100 calcium binding protein B
VGNC:49642
491615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein B
Macaque
S100 calcium binding protein B
Mouse
Rat
Dog
S100 calcium binding protein B
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04271-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (296)
1 – 10 of 296
MLLT11
Tbio
Novelty: 0.04243441
p_int: 0.998038632
p_ni: 0.000068237
p_wrong: 0.001893131
Score: 0.692
Data Source: BioPlex,STRINGDB
LSM5
Tbio
Novelty: 0.12669584
p_int: 0.986460925
p_ni: 0.003386382
p_wrong: 0.010152693
Score: 0.241
Data Source: BioPlex,STRINGDB
AGER
Tchem
Novelty: 0.00061101
Score: 0.999
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.975
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.968
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.967
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.954
Data Source: STRINGDB
CAPZA1
Tbio
Novelty: 0.03448517
Score: 0.95
Data Source: Reactome,STRINGDB
STK38
Tbio
Family: Kinase
Novelty: 0.03242123
Score: 0.944
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  3345.98

PubMed score by year
PubTator Score  3084.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer