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Tbio
KRT1
Keratin, type II cytoskeletal 1

Protein Summary
Description
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252244
  • ENSP00000252244
  • ENSG00000167768

Symbol
  • KRTA
  • K1
  • CK1
  • EHK
  • EHK1
  • EPPK
  • KRT1A
  • NEPPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.9
hub protein
0.79
cellular component
0.65
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.11   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 863   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.11   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
KRT10
Tbio
Novelty:  0.00166073
Score:  0.999
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.997
Data Source:  STRINGDB
KRT2
Tbio
Novelty:  0.01448252
Score:  0.996
Data Source:  STRINGDB
KRT77
Tbio
Novelty:  0.01331186
Score:  0.995
Data Source:  STRINGDB
KRT9
Tbio
Novelty:  0.00787691
Score:  0.965
Data Source:  STRINGDB
PRSS1
Tclin
Family:  Enzyme
Novelty:  0.00157396
Score:  0.95
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.949
Data Source:  STRINGDB
KRT15
Tbio
Novelty:  0.00351898
Score:  0.947
Data Source:  STRINGDB
KRT13
Tbio
Novelty:  0.00468754
Score:  0.946
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Keratinization
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Immune System
Innate Immune System
Keratinization
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
1
1
0
590.4
34.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
0
590.4
34.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
keratin 1
699320
Mouse
MGI:96698
16678
Rat
RGD:1359664
300250
Dog
keratin 1
VGNC:42515
444857
Horse
keratin 1
VGNC:19520
100063302
Species
Name
OMA
EggNOG
Inparanoid
Macaque
keratin 1
Mouse
Rat
Dog
keratin 1
Horse
keratin 1
Publication Statistics
PubMed Score 348.11
PubMed score by year
PubTator Score 1074.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title