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Tbio
KRT6B
Keratin, type II cytoskeletal 6B

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252252
  • ENSP00000252252
  • ENSG00000185479

Symbol
  • K6B
  • KRTL1
  • K6B
  • PC2
  • PC4
  • CK6B
  • CK-6B
  • KRTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
gene perturbation
0.8
PubMedID
0.76
small molecule perturbation
0.69
cell line
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.85   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.85   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.979
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.977
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.97
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.968
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.966
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.95
Data Source:  STRINGDB
KRT15
Tbio
Novelty:  0.00351898
Score:  0.944
Data Source:  STRINGDB
KRT19
Tbio
Novelty:  0.00043162
Score:  0.937
Data Source:  STRINGDB
KRT9
Tbio
Novelty:  0.00787691
Score:  0.936
Data Source:  STRINGDB
KRT13
Tbio
Novelty:  0.00468754
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
1
2
0
1.1
90.6
4
1
1
1.2
81.2
non-melanoma skin carcinoma
1
1
0
1.3
54.4
balding measurement
1
1
1
26.5
cutaneous squamous cell carcinoma
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
0
1.1
90.6
1
1.2
81.2
non-melanoma skin carcinoma
0
1.3
54.4
balding measurement
1
26.5
cutaneous squamous cell carcinoma
1
5.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1100845
16687
Dog
keratin 6A
486523
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
keratin 6A
Publication Statistics
PubMed Score 647.85
PubMed score by year
PubTator Score 92.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title