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Tclin
CD3D
T-cell surface glycoprotein CD3 delta chain

Protein Summary
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300692
  • ENSP00000300692
  • ENSG00000167286
  • ENST00000392884
  • ENSP00000376622

Symbol
  • T3D
  • T3D
  • IMD19
  • CD3-DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
biological process
0.71
tissue sample
0.7
small molecule perturbation
0.64
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.41   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 801   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.41   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 801   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (205)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Costimulation by the CD28 family
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Costimulation by the CD28 family
Downstream TCR signaling
Protein-Protein Interactions (336)
1 – 10 of 336
CD3E
Tclin
Novelty: 0.00541492
Score: 0.999
Data Source: Reactome,STRINGDB
CD247
Tbio
Novelty: 0.00275443
Score: 0.995
Data Source: Reactome,STRINGDB
CD3G
Tclin
Novelty: 0.00498635
Score: 0.989
Data Source: Reactome,STRINGDB
CD8B
Tbio
Novelty: 0.00571233
Score: 0.987
Data Source: Reactome,STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.00136499
Score: 0.986
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00040453
Score: 0.985
Data Source: Reactome,STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00113895
Score: 0.976
Data Source: STRINGDB
CD8A
Tbio
Novelty: 0.00003113
Score: 0.973
Data Source: Reactome,STRINGDB
TRAT1
Tbio
Novelty: 0.00064556
Score: 0.964
Data Source: STRINGDB
CD28
Tbio
Novelty: 0.00051946
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  275.41

PubMed score by year
PubTator Score  93.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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