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Tchem
CD74
HLA class II histocompatibility antigen gamma chain

Protein Summary
Description
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been ide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000009530
  • ENSP00000009530
  • ENSG00000019582
  • ENST00000353334
  • ENSP00000230685
  • ENST00000377795
  • ENSP00000367026

Symbol
  • DHLAG
  • II
  • p33
  • DHLAG
  • HLADG
  • Ia-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.9
molecular function
0.88
cellular component
0.82
small molecule perturbation
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.81   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 1947   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.81   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 1947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD74 molecule
VGNC:6387
462191
Macaque
CD74 molecule
710820
Mouse
MGI:96534
16149
Rat
RGD:2313
25599
Dog
CD74 molecule
VGNC:38972
479329
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD74 molecule
Macaque
CD74 molecule
Mouse
Rat
Dog
CD74 molecule
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Hemostasis
Immune System
MHC class II antigen presentation
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (256)
1 – 10 of 256
TM4SF20
Tbio
Novelty: 0.21582226
p_int: 0.999983356
p_ni: 0.000016409
p_wrong: 2.35e-7
Score: 0.29
Data Source: BioPlex,STRINGDB
COPG1
Tbio
Novelty: 0.01331193
p_int: 0.873861579
p_ni: 0.126138421
Score: 0.816
Data Source: BioPlex,STRINGDB
COPG2
Tbio
Novelty: 0.06126837
p_int: 0.764704226
p_ni: 0.235295774
Score: 0.943
Data Source: BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.999
Data Source: Reactome,STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  388.81

PubMed score by year
PubTator Score  211.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer