Tchem CD74 HLA class II histocompatibility antigen gamma chain

Protein Summary

Description

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P04233
• A8K7R1
• B4DNE8
• D3DQG3
• D3DQG4
• Q14597
• Q29832
• Q5U0J8
• Q8SNA0
• Q8WLP6

Gene Name

• CD74

Ensembl ID

• ENST00000009530
• ENSP00000009530
• ENSG00000019582
• ENST00000353334
• ENSP00000230685
• ENST00000377795
• ENSP00000367026

Symbol

• DHLAG
• II
• p33
• DHLAG
• HLADG
• Ia-GAMMA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.9
molecular function	0.88
cellular component	0.82
small molecule perturbation	0.77

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Hla Class Ii Histocompatibility Antigen Gamma Chain

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Hla Class Ii Histocompatibility Antigen Gamma Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.36   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 1947   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.36   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 1947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0